DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SPOP_SBC_1

Location: 3900:3904

E3 ligase: SPOP

DEGRON score: 0.8153

ASA_SCORE: 81.02

COIL: 0.8344

CONS_SCORE: 0.2784

DSS_SCORE: 0.4412

HELIX: 0.1146

FCONS_SCORE: 0.9748

RIG_SCORE: 0.7407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3903A	TCGA-CK-4951	COAD	TCGA	ALTTS	DEG_SPOP_SBC_1	0.7139
p.T3903A	DO10582	COAD	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7139
p.C3906S	TCGA-CQ-7071	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.2778
p.C3906S	DO49069	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2778
p.P3914A	TCGA-GM-A2D9	BRCA	TCGA	ALTTS	DEG_SPOP_SBC_1	0.0556
p.P3914A	DO4810	BRCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.0556
p.T3898P	DO227802	COCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2778
p.T3903N	DO228986	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7055
p.V3909L	DO50790	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.V3907I	DO228898	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.25
p.E3896K	DO230942	LUSC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.E3896K	SIDM01664	Prostate Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.E3896K	ACH-000952	Prostate Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	0.2222
p.P3914S	DO222595	MELA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.0556
p.S3905P	ACH-001991	Primary	CCLE	ALTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons