DegronMD

Uniprot ID: Q9Y3R5

Source protein: Protein dopey-2

Source gene: DOP1B

Class: DEG_SPOP_SBC_1

Location: 1204:1208

E3 ligase: SPOP

DEGRON score: 0.8427

ASA_SCORE: 81.26

COIL: 0.4538

CONS_SCORE: 0.2637

DSS_SCORE: 0.353

HELIX: 0.5406

FCONS_SCORE: 1.0693

RIG_SCORE: 0.806

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1217S	SIDM00582	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00435	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01020	Plasma Cell Myeloma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00615	Hepatocellular Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00411	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00491	Thyroid Gland Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00781	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00568	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00351	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00562	Breast Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01045	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00252	Biliary Tract Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00280	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01061	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00655	Other Solid Cancers	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00271	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00469	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00368	Small Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00579	Neuroblastoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00233	T-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00591	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00531	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01498	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01471	Chronic Myelogenous Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00780	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01469	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01435	Hepatocellular Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM00959	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217M	SIDM00789	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.R1217M	HCT-15	large_intestine	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALTTS

Degron related mutations and impact score

Drug responses associated with DOP1B mutations

All proteins holding degron of ALTTS