DegronMD

Uniprot ID: Q5T1M5

Source protein: FK506-binding protein 15

Source gene: FKBP15

Class: DEG_SPOP_SBC_1

Location: 998:1002

E3 ligase: SPOP

DEGRON score: 0.6317

ASA_SCORE: 85.12

COIL: 0.8948

CONS_SCORE: 0.4091

DSS_SCORE: 0.7344

HELIX: 0.0468

FCONS_SCORE: 1.0455

RIG_SCORE: 0.6502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V992I	TCGA-AA-3672	COAD	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1667
p.V992I	DO9010	COAD	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.T1000P	TCGA-EO-A22U	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.7031
p.T1000P	DO43755	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7031
p.P993T	DO228483	BRCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.P993T	DO234285	ESAD	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.P993T	DO229480	LAML	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.A998T	DO228035	EOPC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7139
p.T1001N	DO229008	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7055
p.Q1003L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.3056
p.Q1003L	ACH-000841	Lung Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	0.3056
p.Q1003L	NCI-H2087	lung	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons