DegronMD

Uniprot ID: Q9H422

Source protein: Homeodomain-interacting protein kinase 3

Source gene: HIPK3

Class: DEG_SPOP_SBC_1

Location: 592:596

E3 ligase: SPOP

DEGRON score: 0.9044

ASA_SCORE: 75.94

COIL: 0.7894

CONS_SCORE: 0.3886

DSS_SCORE: 0.2687

HELIX: 0.1324

FCONS_SCORE: 1.0897

RIG_SCORE: 0.7423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G586R	TCGA-2W-A8YY	CESC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586R	TCGA-BR-8081	STAD	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586R	DO223732	CESC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586R	DO38795	STAD	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586R	SIDM00210	Ovarian Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.A597T	TCGA-CR-6484	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.3056
p.A597T	DO15206	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.3056
p.R589I	TCGA-D1-A16X	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.25
p.R589I	DO41799	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.25
p.V600L	TCGA-YG-AA3O	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.2222
p.V600L	DO51299	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.H598Y	DO222365	BTCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2778
p.Q591H	DO228974	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.3056
p.G586E	SIDM00333	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586E	ACH-000988	Endometrial/Uterine Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	0.1667
p.G586E	MFE-319	endometrium	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons