DegronMD - Q9H422(HIPK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G586R	TCGA-2W-A8YY	CESC	TCGA	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586R	TCGA-BR-8081	STAD	TCGA	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586R	DO223732	CESC	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586R	DO38795	STAD	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586R	SIDM00210	Ovarian Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.N581H	TCGA-AX-A2HC	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1389
p.N581H	DO41572	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1389
p.A597T	TCGA-CR-6484	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.A597T	DO15206	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.R589I	TCGA-D1-A16X	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.R589I	DO41799	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.V600L	TCGA-YG-AA3O	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.V600L	DO51299	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2222
p.H598Y	DO222365	BTCA	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.Q591H	DO228974	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.3056
p.S572L	DO45223	LIRI	ICGC	VASSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7667
p.G586E	SIDM00333	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586E	ACH-000988	Endometrial/Uterine Cancer	CCLE	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.G586E	MFE-319	endometrium	COSMIC	ALTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667

Kaplan plot for HIPK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIPK3

UniProt ID: Q9H422

Entrez ID: 10114

Protein name: Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIPK3 in