DegronMD - Q8IZQ8(MYOCD)

GO - Biological processes (BP): cardiac muscle cell differentiation [GO:0055007]; cardiac ventricle development [GO:0003231]; cardiocyte differentiation [GO:0035051]; cellular component maintenance [GO:0043954]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; lung alveolus development [GO:0048286]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of skeletal muscle cell differentiation [GO:2001015]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac vascular smooth muscle cell differentiation [GO:2000724]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003257]; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000721]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of histone acetylation [GO:0035065]; regulation of myoblast differentiation [GO:0045661]; regulation of phenotypic switching [GO:1900239]; regulation of smooth muscle cell differentiation [GO:0051150]; response to hypoxia [GO:0001666]; smooth muscle cell differentiation [GO:0051145]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell differentiation [GO:0055012] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R400Q	TCGA-12-0619	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.R400Q	DO12898	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.R402Q	TCGA-19-5956	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	TCGA-EO-A22U	UCEC	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	TCGA-VQ-A91K	STAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	DO13863	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	DO220862	MELA	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	DO51785	STAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.R402Q	DO43755	UCEC	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6218
p.S634F	TCGA-19-5956	GBM	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.S634F	DO13863	GBM	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.S634F	DO229491	SKCA	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.P631T	TCGA-22-4593	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2222
p.P631T	DO27018	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2222
p.I904S	TCGA-23-2649	OV	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.2222
p.I904S	TCGA-23-2649	OV	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.I904S	DO31779	OV	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.2222
p.I904S	DO31779	OV	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.T621S	TCGA-24-1850	OV	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2778
p.T621S	DO29638	OV	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2778
p.T395M	TCGA-28-1746	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1667
p.T395M	DO13564	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1667
p.N622K	TCGA-34-5232	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.N622K	DO27168	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.3056
p.P413T	TCGA-38-7271	LUAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1389
p.P413T	DO26142	LUAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1389
p.D399E	TCGA-3N-A9WC	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.2778
p.D399E	DO51234	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.2778
p.P906A	TCGA-91-6828	LUAD	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7503
p.P906A	DO26150	LUAD	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7503
p.S710C	TCGA-AC-A23H	BRCA	TCGA	PPSY	ITCH	720:723	Mutation rewiring degron network	0.0556
p.S710C	TCGA-D5-6531	COAD	TCGA	PPSY	ITCH	720:723	Mutation rewiring degron network	0.0556
p.S710C	DO2401	BRCA	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.0556
p.S710C	DO7983	COAD	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.0556
p.G392D	TCGA-AN-A0AK	BRCA	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0833
p.G392D	DO1608	BRCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0833
p.F890L	TCGA-B5-A11N	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	TCGA-EO-A3B0	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	TCGA-EY-A1G8	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	TCGA-EY-A1GI	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	DO219773	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	DO43578	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	DO41211	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.F890L	DO41458	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.H637N	TCGA-BR-A4J4	STAD	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.H637N	DO38671	STAD	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.E903K	TCGA-BT-A20V	BLCA	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.E903K	TCGA-BT-A20V	BLCA	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.E903K	TCGA-CN-4723	HNSC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.E903K	TCGA-CN-4723	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.E903K	DO689	BLCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.E903K	DO689	BLCA	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.E903K	DO14830	HNSC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.E903K	DO14830	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.T344A	TCGA-CG-5721	STAD	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.T344A	DO38192	STAD	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.P345L	TCGA-CN-5360	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.P345L	TCGA-D3-A8GB	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.P345L	DO14662	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.P345L	DO50280	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.H613Y	TCGA-D3-A3C8	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.H613Y	DO47636	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.0556
p.G416V	TCGA-D3-A3CE	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0556
p.G416V	DO37405	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0556
p.S917L	TCGA-D3-A8GQ	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	TCGA-EE-A2MD	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	TCGA-ER-A19M	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	TCGA-W3-AA1R	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	DO229177	LMS	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	DO37851	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	DO37798	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	DO51275	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.S917L	DO51246	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1389
p.M398I	TCGA-D7-A4Z0	STAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.25
p.M398I	DO229459	SKCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.25
p.M398I	DO47765	STAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.25
p.G885E	TCGA-D9-A6EC	SKCM	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1111
p.G885E	DO50291	SKCM	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1111
p.G885E	SIDM01561	Melanoma	GDSC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1111
p.G722E	TCGA-DX-AB2E	SARC	TCGA	PPSY	ITCH	720:723	Mutation altering degron motif	0.7199
p.G722E	DO220073	SARC	ICGC	PPSY	ITCH	720:723	Mutation altering degron motif	0.7199
p.G722E	DO218863	SKCA	ICGC	PPSY	ITCH	720:723	Mutation altering degron motif	0.7199
p.E328K	TCGA-EE-A29D	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.E328K	DO218440	BTCA	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.E328K	DO38123	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.P348L	TCGA-EE-A2GS	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.P348L	DO37465	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.T393I	TCGA-EE-A2MR	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1111
p.T393I	DO37819	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1111
p.P411Q	TCGA-EE-A3AC	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1944
p.P411Q	DO37631	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1944
p.D897Y	TCGA-EO-A3AV	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.7325
p.D897Y	DO222762	COCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.7325
p.D897Y	DO52412	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.7325
p.E616K	TCGA-ER-A19D	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.E616K	DO37750	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1389
p.A901V	TCGA-EY-A215	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.3056
p.A901V	TCGA-EY-A215	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.A901V	DO42665	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.3056
p.A901V	DO42665	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.T339M	TCGA-EY-A4KR	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.T339M	DO48179	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.P334S	TCGA-FI-A2D5	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6752
p.P334S	DO41331	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6752
p.G416R	TCGA-FR-A726	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0556
p.G416R	DO48665	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.0556
p.E325K	TCGA-GF-A6C9	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.E325K	DO51254	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.S617Y	TCGA-K4-A54R	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1667
p.S617Y	DO48611	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1667
p.R400W	TCGA-KK-A7B4	PRAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.R400W	DO234159	ESAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.R400W	DO219311	PRAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.R400W	DO230449	UTCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.3056
p.N327H	TCGA-QS-A5YQ	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.N327H	DO49073	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.L905V	TCGA-W3-A825	SKCM	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1944
p.L905V	TCGA-W3-A825	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.L905V	DO51272	SKCM	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1944
p.L905V	DO51272	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.F899L	TCGA-XF-AAMZ	BLCA	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.6981
p.F899L	DO219051	BLCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.6981
p.A712S	DO52645	BOCA	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.1111
p.T395A	DO234225	ESAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.1667
p.T914I	DO48294	ESCA	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2222
p.C730Y	DO233944	GACA	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.1389
p.S342N	DO231998	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.G409C	DO228971	LICA	ICGC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.25
p.L346F	DO229038	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.G719S	DO50934	LICA	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.3056
p.P724T	DO25847	LUAD	ICGC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.3056
p.P348S	DO220875	MELA	ICGC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.P635S	DO222550	MELA	ICGC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.1111
p.D884H	DO27905	ORCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.0833
p.S919F	DO49075	PACA	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.0833
p.L909P	DO36822	READ	ICGC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7582
p.M887I	DO218860	SKCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1667
p.D888N	DO227688	SKCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1944
p.D406N	SIDM00007	Other Solid Cancers	GDSC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6932
p.D406N	ACH-001550	Skin Cancer	CCLE	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6932
p.D406N	MCC13	skin	COSMIC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6932
p.L401I	SIDM00193	Colorectal Carcinoma	GDSC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6063
p.L401I	ACH-000991	Colon/Colorectal Cancer	CCLE	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6063
p.L401I	SNU-81	large intestine	COSMIC	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation altering degron motif	0.6063
p.S347P	SIDM00878	Breast Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.S347P	ACH-000930	Breast Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.S347P	HCC1569	breast	COSMIC	PNSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.G721W	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	720:723	Mutation altering degron motif	0.7825
p.G721W	NCI-H2172	lung	COSMIC	PPSY	ITCH	720:723	Mutation altering degron motif	0.7825
p.L629I	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation rewiring degron network	0.2778
p.V623L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.6765
p.V623L	ACH-000888	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.6765
p.V623L	NCI-H1793	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	623:627	Mutation altering degron motif	0.6765
p.G907D	SIDM01608	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7198
p.S905G	ACH-000218	Leukemia	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1944
p.S905G	ACH-000218	Leukemia	CCLE	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.S905G	PL-21	haematopoietic and lymphoid tissue	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.1944
p.S905G	PL-21	haematopoietic and lymphoid tissue	COSMIC	ALTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.D399Y	ACH-000436	Myeloma	CCLE	LRPFQD	LIG_APCC_ABBA_1	401:406	Mutation rewiring degron network	0.2778
p.M890T	ACH-000957	Colon/Colorectal Cancer	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.M890T	LS-180	large intestine	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.25
p.L895F	ACH-001353	Pancreatic Cancer	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation altering degron motif	0.587
p.S715L	ACH-002143	Skin Cancer	CCLE	PPSY	ITCH	720:723	Mutation rewiring degron network	0.1944
p.S715L	IST-MEL1	skin	COSMIC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.1944
p.T883S	MIA-PaCa-2	pancreas	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	893:900	Mutation rewiring degron network	0.0556
p.D725H	D-263MG	central nervous system	COSMIC	PPSY	ITCH	720:723	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOCD

UniProt ID: Q8IZQ8

Entrez ID: 93649

Protein name: Myocardin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOCD in