DegronMD

Uniprot ID: Q8IZQ8

Source protein: Myocardin

Source gene: MYOCD

Class: DEG_SPOP_SBC_1

Location: 623:627

E3 ligase: SPOP

DEGRON score: 0.8694

ASA_SCORE: 80.08

COIL: 0.8056

CONS_SCORE: 0.3334

DSS_SCORE: 0.4324

HELIX: 0.1534

FCONS_SCORE: 0.8987

RIG_SCORE: 0.7239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S634F	TCGA-19-5956	GBM	TCGA	VLSST	DEG_SPOP_SBC_1	0.1389
p.S634F	DO13863	GBM	ICGC	VLSST	DEG_SPOP_SBC_1	0.1389
p.S634F	DO229491	SKCA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1389
p.P631T	TCGA-22-4593	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	0.2222
p.P631T	DO27018	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	0.2222
p.T621S	TCGA-24-1850	OV	TCGA	VLSST	DEG_SPOP_SBC_1	0.2778
p.T621S	DO29638	OV	ICGC	VLSST	DEG_SPOP_SBC_1	0.2778
p.N622K	TCGA-34-5232	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	0.3056
p.N622K	DO27168	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	0.3056
p.H637N	TCGA-BR-A4J4	STAD	TCGA	VLSST	DEG_SPOP_SBC_1	0.0556
p.H637N	DO38671	STAD	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.H613Y	TCGA-D3-A3C8	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.0556
p.H613Y	DO47636	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.E616K	TCGA-ER-A19D	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.1389
p.E616K	DO37750	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.1389
p.S617Y	TCGA-K4-A54R	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	0.1667
p.S617Y	DO48611	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1667
p.P635S	DO222550	MELA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.L629I	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.2778
p.V623L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.6765
p.V623L	ACH-000888	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.6765
p.V623L	NCI-H1793	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons