DegronMD - Q9NS87(KIF15)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P65H	TCGA-37-3789	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.P65H	DO26743	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.S159N	TCGA-AP-A059	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1111
p.S159N	DO41361	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1111
p.C50Y	TCGA-AX-A1CE	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.C50Y	DO42280	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.T57M	TCGA-B5-A0K6	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7423
p.T57M	TCGA-BR-6852	STAD	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7423
p.T57M	DO38202	STAD	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7423
p.T57M	DO40808	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7423
p.E1325D	TCGA-BR-8361	STAD	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.0833
p.Q1303H	TCGA-BR-8363	STAD	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.1944
p.Q1303K	TCGA-D3-A3C8	SKCM	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.1944
p.R60W	TCGA-D3-A51G	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60W	DO47700	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60W	SIDM00533	Pancreatic Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60W	SIDM00989	Bladder Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60W	HuP-T3	pancreas	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60W	BFTC-905	urinary tract	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.M1315L	TCGA-D9-A1JW	SKCM	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation altering degron motif	0.5999
p.M1315L	DO37786	SKCM	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation altering degron motif	0.5999
p.S58T	TCGA-D9-A6EC	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.3056
p.S58T	DO50291	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.3056
p.L161F	TCGA-DI-A1BU	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1667
p.L161F	DO42023	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1667
p.E66Q	TCGA-DK-A6B6	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0833
p.E66Q	DO48576	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0833
p.D44H	TCGA-DX-A3U8	SARC	TCGA	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0833
p.D44H	DO219975	SARC	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0833
p.M1315V	TCGA-FI-A2D5	UCEC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation altering degron motif	0.6097
p.E172K	TCGA-FI-A3PV	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.7022
p.E172K	DO48169	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.7022
p.E1314K	TCGA-IR-A3LK	CESC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation altering degron motif	0.591
p.E1314K	DO44299	CESC	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation altering degron motif	0.591
p.E1320Q	TCGA-IR-A3LK	CESC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.2222
p.S1299Y	DO223015	ESCA	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.0833
p.A43S	DO229025	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0556
p.E66K	DO46473	OV	ICGC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0833
p.R60Q	SIDM01169	Ovarian Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60Q	LU-99A	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.R60Q	TOV-21G	ovary	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.L161P	SIDM00082	Melanoma	GDSC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1667
p.L161P	ACH-001190	Skin Cancer	CCLE	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1667
p.L161P	SK-MEL-2	skin	COSMIC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1667
p.E1306V	SIDM01112	Osteosarcoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.2778
p.E1306V	ACH-000748	Bone Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.2778
p.E1306V	SJSA-1	bone	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.2778
p.T1322A	SIDM00217	Colorectal Carcinoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.1667
p.T1322A	ACH-000999	Colon/Colorectal Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.1667
p.T1322A	SNU-1040	large intestine	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.1667
p.S1299F	SIDM00534	Colorectal Carcinoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.0833
p.S1299F	ACH-000986	Colon/Colorectal Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.0833
p.S1299F	HT-115	large intestine	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.0833
p.E1317K	ACH-000454	Lung Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	1308:1316	Mutation rewiring degron network	0.3056
p.L177V	ACH-001864	Bile Duct Cancer	CCLE	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1944
p.D43A	LS-180	large intestine	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0556
p.Y49D	IST-MES1	pleura	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.T47S	HC-1	haematopoietic and lymphoid tissue	COSMIC	VLSST	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.S182L	H2810	pleura	COSMIC	IEIYNE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF15

UniProt ID: Q9NS87

Entrez ID: 56992

Protein name: Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KIF15 in