DegronMD

Uniprot ID: Q9NS87

Source protein: Kinesin-like protein KIF15

Source gene: KIF15

Class: DEG_SPOP_SBC_1

Location: 53:57

E3 ligase: SPOP

DEGRON score: 0.9169

ASA_SCORE: 71.56

COIL: 0.7096

CONS_SCORE: 0.2392

DSS_SCORE: 0.3529

HELIX: 0.0156

FCONS_SCORE: 0.9612

RIG_SCORE: 0.7453

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T57M	TCGA-B5-A0K6	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.7423
p.T57M	TCGA-BR-6852	STAD	TCGA	VLSST	DEG_SPOP_SBC_1	0.7423
p.T57M	DO38202	STAD	ICGC	VLSST	DEG_SPOP_SBC_1	0.7423
p.T57M	DO40808	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.7423
p.S58T	TCGA-D9-A6EC	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.3056
p.S58T	DO50291	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.3056
p.C50Y	TCGA-AX-A1CE	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.25
p.C50Y	DO42280	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	TCGA-D3-A51G	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	DO47700	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	SIDM00533	Pancreatic Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	SIDM00989	Bladder Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	HuP-T3	pancreas	COSMIC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60W	BFTC-905	urinary_tract	COSMIC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60Q	SIDM01169	Ovarian Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60Q	LU-99A	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.25
p.R60Q	TOV-21G	ovary	COSMIC	VLSST	DEG_SPOP_SBC_1	0.25
p.Y49D	IST-MES1	pleura	COSMIC	VLSST	DEG_SPOP_SBC_1	0.2222
p.T47S	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VLSST	DEG_SPOP_SBC_1	0.1667
p.P65H	TCGA-37-3789	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.P65H	DO26743	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.E66Q	TCGA-DK-A6B6	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	0.0833
p.E66Q	DO48576	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	0.0833
p.D44H	TCGA-DX-A3U8	SARC	TCGA	VLSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 25 of 29 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...

Showing 1 to 7 of 7 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons