DegronMD

Uniprot ID: Q16890

Source protein: Tumor protein D53

Source gene: TPD52L1

Class: DEG_SPOP_SBC_1

Location: 178:182

E3 ligase: SPOP

DEGRON score: 0.9655

ASA_SCORE: 65.9

COIL: 0.5174

CONS_SCORE: 0.4436

DSS_SCORE: 0.5406

HELIX: 0.4774

FCONS_SCORE: 1.0612

RIG_SCORE: 0.7317

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A187T	TCGA-D1-A1O7	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.1944
p.P170H	TCGA-D3-A1Q1	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.P170H	TCGA-ER-A19P	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.P170H	DO37445	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.P170H	DO47623	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.T168M	TCGA-DF-A2KU	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.0556
p.A183V	TCGA-YG-AA3N	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.3056
p.S186G	TCGA-ZP-A9CV	LIHC	TCGA	VLSST	DEG_SPOP_SBC_1	0.6667
p.T187M	DO233888	GACA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1944
p.S185I	DO228948	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	0.25
p.G172C	DO229036	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1667
p.S191G	DO52328	LIHC	ICGC	VLSST	DEG_SPOP_SBC_1	0.0833
p.A188V	DO51298	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	0.1667
p.G172S	DO48174	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1667
p.T173M	DO223286	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1944
p.A192T	DO41139	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.V183D	SIDM00569	Osteosarcoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	SIDM00273	Glioblastoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	EC-GI-10	oesophagus	COSMIC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	GI-1	central_nervous_system	COSMIC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	NY	bone	COSMIC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V183D	KNS-62	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.3056
p.V178D	ACH-000305	Esophageal Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	ACH-000321	Leukemia	CCLE	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	ACH-000756	Brain Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	ACH-000858	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	ACH-002178	Bone Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	NY	bone	COSMIC	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	GI-1	central_nervous_system	COSMIC	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	EC-GI-10	oesophagus	COSMIC	VLSST	DEG_SPOP_SBC_1	0.7785
p.V178D	KNS-62	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSST

Degron related mutations and impact score

Drug responses associated with TPD52L1 mutations

All proteins holding degron of VLSST