DegronMD - Q8NI08(NCOA7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E212K	TCGA-05-4382	LUAD	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1111
p.E212K	TCGA-05-4382	LUAD	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.E212K	DO24900	LUAD	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1111
p.E212K	DO24900	LUAD	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.L517S	TCGA-19-2621	GBM	TCGA	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation rewiring degron network	0.3056
p.L517S	DO11100	GBM	ICGC	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation rewiring degron network	0.3056
p.V218L	TCGA-21-1083	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.V218L	DO26769	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.D396Y	TCGA-25-2398	OV	TCGA	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.0833
p.D396Y	DO31250	OV	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.0833
p.D214Y	TCGA-A5-A0G2	UCEC	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.0556
p.D214Y	TCGA-A5-A0G2	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.D214Y	DO41235	UCEC	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.0556
p.D214Y	DO41235	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.S208L	TCGA-AJ-A3EL	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.8778
p.S208L	DO41542	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.8778
p.P191H	TCGA-AP-A0LM	UCEC	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1944
p.P191H	TCGA-AP-A0LM	UCEC	TCGA	SPGATVSPS	DEG_SIAH_1	173:181	Mutation rewiring degron network	0.0556
p.P191H	DO43306	UCEC	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1944
p.P191H	DO43306	UCEC	ICGC	SPGATVSPS	DEG_SIAH_1	173:181	Mutation rewiring degron network	0.0556
p.E215G	TCGA-BG-A0VW	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.E215G	DO40843	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.E204K	TCGA-BR-6452	STAD	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.591
p.E204K	DO38404	STAD	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.591
p.D194N	TCGA-D8-A27G	BRCA	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2778
p.D194N	DO5465	BRCA	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.2778
p.S209P	TCGA-DF-A2KN	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7863
p.S209P	DO223282	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7863
p.E402D	TCGA-EO-A22R	UCEC	TCGA	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.25
p.E402D	DO42713	UCEC	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.25
p.E407K	TCGA-LK-A4NY	MESO	TCGA	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation altering degron motif	0.7022
p.S399A	DO230334	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO222809	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO229005	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO230659	LAML	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO231140	LAML	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO229047	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.S399A	DO230538	LUSC	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1667
p.D413H	DO233828	GACA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.2222
p.E215D	DO228948	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.L419F	DO229018	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.0556
p.A199S	DO229029	LICA	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.6477
p.R168S	DO229037	LICA	ICGC	SPGATVSPS	DEG_SIAH_1	173:181	Mutation rewiring degron network	0.1944
p.S398T	DO34584	PACA	ICGC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1389
p.N510D	DO37901	SKCM	ICGC	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation rewiring degron network	0.3056
p.N512H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation altering degron motif	0.6312
p.N512H	ACH-000795	Leukemia	CCLE	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation altering degron motif	0.6312
p.N512H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation altering degron motif	0.6312
p.R197Q	SIDM00534	Colorectal Carcinoma	GDSC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.7329
p.R197Q	ACH-000986	Colon/Colorectal Cancer	CCLE	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.7329
p.R197Q	HT-115	large intestine	COSMIC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.7329
p.E212V	ACH-000872	Lung Cancer	CCLE	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation rewiring degron network	0.1111
p.E212V	ACH-000872	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2778
p.I513M	ACH-001148	Lymphoma	CCLE	LNIHED	LIG_APCC_ABBA_1	511:516	Mutation altering degron motif	0.6507
p.D185N	NCI-H727	lung	COSMIC	SPGATVSPS	DEG_SIAH_1	173:181	Mutation rewiring degron network	0.2222
p.M168V	LS-180	large intestine	COSMIC	SPGATVSPS	DEG_SIAH_1	173:181	Mutation rewiring degron network	0.1944
p.N397H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	AKENF	DEG_APCC_KENBOX_2	405:409	Mutation rewiring degron network	0.1111
p.R177Q	NCI-H1770	lung	COSMIC	SPGATVSPS	DEG_SIAH_1	173:181	Mutation altering degron motif	0.7329
p.I201T	U-698-M	haematopoietic and lymphoid tissue	COSMIC	ARKALKPIE	DEG_APCC_DBOX_1	196:204	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA7

UniProt ID: Q8NI08

Entrez ID: 135112

Protein name: Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA7 in