DegronMD

Uniprot ID: Q8NI08

Source protein: Nuclear receptor coactivator 7

Source gene: NCOA7

Class: DEG_APCC_DBOX_1

Location: 196:204

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 96.3667

COIL: 0.569

CONS_SCORE: 0.3788

DSS_SCORE: 0.4056

HELIX: 0.4173

FCONS_SCORE: 1.1925

RIG_SCORE: 0.7745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E212K	TCGA-05-4382	LUAD	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	0.1111
p.E212K	DO24900	LUAD	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.1111
p.D214Y	TCGA-A5-A0G2	UCEC	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	0.0556
p.D214Y	DO41235	UCEC	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.0556
p.P191H	TCGA-AP-A0LM	UCEC	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	0.1944
p.P191H	DO43306	UCEC	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.1944
p.E204K	TCGA-BR-6452	STAD	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	0.591
p.E204K	DO38404	STAD	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.591
p.D194N	TCGA-D8-A27G	BRCA	TCGA	ARKALKPIE	DEG_APCC_DBOX_1	0.2778
p.D194N	DO5465	BRCA	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.2778
p.A199S	DO229029	LICA	ICGC	ARKALKPIE	DEG_APCC_DBOX_1	0.6477
p.R197Q	SIDM00534	Colorectal Carcinoma	GDSC	ARKALKPIE	DEG_APCC_DBOX_1	0.7329
p.R197Q	ACH-000986	Colon/Colorectal Cancer	CCLE	ARKALKPIE	DEG_APCC_DBOX_1	0.7329
p.R197Q	HT-115	large_intestine	COSMIC	ARKALKPIE	DEG_APCC_DBOX_1	0.7329
p.E212V	ACH-000872	Lung Cancer	CCLE	ARKALKPIE	DEG_APCC_DBOX_1	0.1111
p.I201T	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	ARKALKPIE	DEG_APCC_DBOX_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI08	Nuclear receptor coactivator 7	DEG_APCC_DBOX_1	196:204	ARKALKPIE	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons