DegronMD

Uniprot ID: Q8NI08

Source protein: Nuclear receptor coactivator 7

Source gene: NCOA7

Class: LIG_APCC_ABBA_1

Location: 511:516

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9742

ASA_SCORE: 89.05

COIL: 0.5765

CONS_SCORE: 0.3005

DSS_SCORE: 0.4013

HELIX: 0.3478

FCONS_SCORE: 1.0119

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L517S	TCGA-19-2621	GBM	TCGA	LNIHED	LIG_APCC_ABBA_1	0.3056
p.L517S	DO11100	GBM	ICGC	LNIHED	LIG_APCC_ABBA_1	0.3056
p.N510D	DO37901	SKCM	ICGC	LNIHED	LIG_APCC_ABBA_1	0.3056
p.N512H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	LNIHED	LIG_APCC_ABBA_1	0.6312
p.N512H	ACH-000795	Leukemia	CCLE	LNIHED	LIG_APCC_ABBA_1	0.6312
p.N512H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	LNIHED	LIG_APCC_ABBA_1	0.6312
p.I513M	ACH-001148	Lymphoma	CCLE	LNIHED	LIG_APCC_ABBA_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI08	Nuclear receptor coactivator 7	LIG_APCC_ABBA_1	511:516	LNIHED	APC,CDC20,FZR1	0.9742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons