DegronMD

Uniprot ID: Q8NI08

Source protein: Nuclear receptor coactivator 7

Source gene: NCOA7

Class: DEG_APCC_KENBOX_2

Location: 405:409

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7086

ASA_SCORE: 100.82

COIL: 0.5596

CONS_SCORE: 0.3205

DSS_SCORE: 0.5228

HELIX: 0.3876

FCONS_SCORE: 1.1198

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D396Y	TCGA-25-2398	OV	TCGA	AKENF	DEG_APCC_KENBOX_2	0.0833
p.D396Y	DO31250	OV	ICGC	AKENF	DEG_APCC_KENBOX_2	0.0833
p.E402D	TCGA-EO-A22R	UCEC	TCGA	AKENF	DEG_APCC_KENBOX_2	0.25
p.E402D	DO42713	UCEC	ICGC	AKENF	DEG_APCC_KENBOX_2	0.25
p.E407K	TCGA-LK-A4NY	MESO	TCGA	AKENF	DEG_APCC_KENBOX_2	0.7022
p.S399A	DO230334	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO222809	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO229005	COCA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO230659	LAML	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO231140	LAML	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO229047	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.S399A	DO230538	LUSC	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.D413H	DO233828	GACA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.2222
p.L419F	DO229018	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.0556
p.S398T	DO34584	PACA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1389
p.N397H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	AKENF	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI08	Nuclear receptor coactivator 7	DEG_APCC_KENBOX_2	405:409	AKENF	APC,CDC20,FZR1	0.7086	More...
Q9UHC6	Contactin-associated protein-like 2	DEG_APCC_KENBOX_2	465:469	AKENF	APC,CDC20,FZR1	0.681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons