DegronMD

Uniprot ID: Q9UHC6

Source protein: Contactin-associated protein-like 2

Source gene: CNTNAP2

Class: DEG_APCC_KENBOX_2

Location: 465:469

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.681

ASA_SCORE: 83.96

COIL: 0.4038

CONS_SCORE: 0.2647

DSS_SCORE: 0.1808

HELIX: 0.0086

FCONS_SCORE: 0.6031

RIG_SCORE: 0.8674

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A479V	TCGA-28-2501	GBM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.0556
p.I474M	TCGA-49-4514	LUAD	TCGA	AKENF	DEG_APCC_KENBOX_2	0.1944
p.I474M	DO23818	LUAD	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.I474V	TCGA-85-6798	LUSC	TCGA	AKENF	DEG_APCC_KENBOX_2	0.1944
p.I474V	DO27295	LUSC	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.K466N	TCGA-91-6836	LUAD	TCGA	AKENF	DEG_APCC_KENBOX_2	0.6918
p.K466N	DO23232	LINC	ICGC	AKENF	DEG_APCC_KENBOX_2	0.6918
p.K466N	DO23854	LUAD	ICGC	AKENF	DEG_APCC_KENBOX_2	0.6918
p.E478K	TCGA-AX-A3G6	UCEC	TCGA	AKENF	DEG_APCC_KENBOX_2	0.0833
p.E478K	DO41668	UCEC	ICGC	AKENF	DEG_APCC_KENBOX_2	0.0833
p.L464I	TCGA-BF-A1Q0	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.3056
p.L464I	DO47374	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.3056
p.R462C	TCGA-EE-A29P	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	TCGA-GN-A26A	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	DO229177	LMS	ICGC	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	DO37861	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	DO37916	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	SIDM01175	Other Sarcomas	GDSC	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	ACH-002309	Sarcoma	CCLE	AKENF	DEG_APCC_KENBOX_2	0.25
p.R462C	SW684	soft_tissue	COSMIC	AKENF	DEG_APCC_KENBOX_2	0.25
p.E460K	TCGA-ER-A19M	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.1944
p.E460K	TCGA-FS-A4FD	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.1944
p.E460K	DO37699	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.E460K	DO37798	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.E467K	TCGA-FR-A726	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	TCGA-GN-A266	SKCM	TCGA	AKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	DO37432	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.7022
p.E467K	DO48665	SKCM	ICGC	AKENF	DEG_APCC_KENBOX_2	0.7022
p.A465D	TCGA-NJ-A55O	LUAD	TCGA	AKENF	DEG_APCC_KENBOX_2	0.6682
p.A465D	DO218946	LUAD	ICGC	AKENF	DEG_APCC_KENBOX_2	0.6682
p.D475N	DO234365	ESAD	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1667
p.L472F	DO223026	ESCA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.25
p.N468H	DO233106	GACA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.7423
p.N468K	DO228405	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.6918
p.A470S	DO229019	LICA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.3056
p.V461I	DO52675	MALY	ICGC	AKENF	DEG_APCC_KENBOX_2	0.2222
p.G476R	DO222632	MELA	ICGC	AKENF	DEG_APCC_KENBOX_2	0.1389
p.I474L	SIDM00846	Cervical Carcinoma	GDSC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.I474L	ACH-001086	Cervical Cancer	CCLE	AKENF	DEG_APCC_KENBOX_2	0.1944
p.I474L	HeLa	cervix	COSMIC	AKENF	DEG_APCC_KENBOX_2	0.1944
p.F469L	SIDM00482	Chronic Myelogenous Leukemia	GDSC	AKENF	DEG_APCC_KENBOX_2	0.587
p.F469L	ACH-002302	Leukemia	CCLE	AKENF	DEG_APCC_KENBOX_2	0.587
p.F469L	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	AKENF	DEG_APCC_KENBOX_2	0.587
p.F469S	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	AKENF	DEG_APCC_KENBOX_2	0.6871
p.F469S	ACH-002102	Lung Cancer	CCLE	AKENF	DEG_APCC_KENBOX_2	0.6871
p.F469S	EMC-BAC-2	lung	COSMIC	AKENF	DEG_APCC_KENBOX_2	0.6871
p.D477N	SIDM01611	Endometrial Carcinoma	GDSC	AKENF	DEG_APCC_KENBOX_2	0.1111
p.D477N	ACH-000996	Endometrial/Uterine Cancer	CCLE	AKENF	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI08	Nuclear receptor coactivator 7	DEG_APCC_KENBOX_2	405:409	AKENF	APC,CDC20,FZR1	0.7086	More...
Q9UHC6	Contactin-associated protein-like 2	DEG_APCC_KENBOX_2	465:469	AKENF	APC,CDC20,FZR1	0.681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKENF

Degron related mutations and impact score

Drug responses associated with CNTNAP2 mutations

All proteins holding degron of AKENF