DegronMD

Uniprot ID: Q8NI08

Source protein: Nuclear receptor coactivator 7

Source gene: NCOA7

Class: DEG_SPOP_SBC_1

Location: 206:210

E3 ligase: SPOP

DEGRON score: 0.9703

ASA_SCORE: 86.12

COIL: 0.8626

CONS_SCORE: 0.3271

DSS_SCORE: 0.4497

HELIX: 0.078

FCONS_SCORE: 0.9072

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E212K	TCGA-05-4382	LUAD	TCGA	VLSST	DEG_SPOP_SBC_1	0.2778
p.E212K	DO24900	LUAD	ICGC	VLSST	DEG_SPOP_SBC_1	0.2778
p.V218L	TCGA-21-1083	LUSC	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.V218L	DO26769	LUSC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.D214Y	TCGA-A5-A0G2	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.2222
p.D214Y	DO41235	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.2222
p.S208L	TCGA-AJ-A3EL	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.8778
p.S208L	DO41542	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.8778
p.E215G	TCGA-BG-A0VW	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.1944
p.E215G	DO40843	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1944
p.S209P	TCGA-DF-A2KN	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.7863
p.S209P	DO223282	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.7863
p.E215D	DO228948	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1944
p.E212V	ACH-000872	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons