DegronMD

Uniprot ID: Q14940

Source protein: Sodium/hydrogen exchanger 5

Source gene: SLC9A5

Class: DEG_SPOP_SBC_1

Location: 546:550

E3 ligase: SPOP

DEGRON score: 0.6553

ASA_SCORE: 69.06

COIL: 0.7954

CONS_SCORE: 0.2937

DSS_SCORE: 0.2951

HELIX: 0.1156

FCONS_SCORE: 0.7787

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G544C	TCGA-AX-A06F	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.2778
p.G544C	DO41752	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.2778
p.V546I	TCGA-BG-A0MT	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.7076
p.V546I	DO41698	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.7076
p.V546I	SIDM01943	Colorectal Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.7076
p.S548F	TCGA-TN-A7HL	HNSC	TCGA	VLSST	DEG_SPOP_SBC_1	0.7982
p.S548F	DO219080	HNSC	ICGC	VLSST	DEG_SPOP_SBC_1	0.7982
p.A536T	DO233709	GACA	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.F539L	DO23336	LINC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1389
p.S559G	DO220955	WT	ICGC	VLSST	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons