DegronMD - Q16890(TPD52L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A187T	TCGA-D1-A1O7	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.P170H	TCGA-D3-A1Q1	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1111
p.P170H	TCGA-ER-A19P	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1111
p.P170H	DO37445	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1111
p.P170H	DO47623	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1111
p.T168M	TCGA-DF-A2KU	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0556
p.A183V	TCGA-YG-AA3N	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.S186G	TCGA-ZP-A9CV	LIHC	TCGA	VLSST	DEG_SPOP_SBC_1	178:182	Mutation blocking phosphorylation signal	0.6667
p.T187M	DO233888	GACA	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.S185I	DO228948	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.25
p.G172C	DO229036	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.S191G	DO52328	LIHC	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.A188V	DO51298	SKCM	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.G172S	DO48174	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.T173M	DO223286	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.A192T	DO41139	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0556
p.V183D	SIDM00569	Osteosarcoma	GDSC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	SIDM00273	Glioblastoma	GDSC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	SIDM01691	Chronic Myelogenous Leukemia	GDSC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	EC-GI-10	oesophagus	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	GI-1	central nervous system	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	NY	bone	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V183D	KNS-62	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.3056
p.V178D	ACH-000305	Esophageal Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	ACH-000321	Leukemia	CCLE	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	ACH-000756	Brain Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	ACH-000858	Lung Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	ACH-002178	Bone Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	NY	bone	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	GI-1	central nervous system	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	EC-GI-10	oesophagus	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785
p.V178D	KNS-62	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	178:182	Mutation altering degron motif	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPD52L1

UniProt ID: Q16890

Entrez ID: 7164

Protein name: Tumor protein D53 (hD53) (Tumor protein D52-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPD52L1 in