DegronMD

Uniprot ID: Q99081

Source protein: Transcription factor 12

Source gene: TCF12

Class: DEG_SPOP_SBC_1

Location: 482:486

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 78.16

COIL: 0.8666

CONS_SCORE: 0.3898

DSS_SCORE: 0.5171

HELIX: 0.0646

FCONS_SCORE: 1.1248

RIG_SCORE: 0.6778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L480F	TCGA-2W-A8YY	CESC	TCGA	VLSST	DEG_SPOP_SBC_1	0.2778
p.R494W	TCGA-AA-A022	COAD	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.R494L	TCGA-EE-A184	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	0.1111
p.G476A	TCGA-XF-A9SK	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	0.1667
p.Q476E	DO461	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1667
p.L472R	DO50864	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.L472F	DO220890	MELA	ICGC	VLSST	DEG_SPOP_SBC_1	0.0556
p.L474I	DO43682	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111
p.A479V	DO41752	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.25
p.A479V	CW-2	large_intestine	COSMIC	VLSST	DEG_SPOP_SBC_1	0.25
p.A482V	SIDM00875	Breast Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.6936
p.A482V	ACH-000624	Breast Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	0.6936
p.A482V	HCC1806	breast	COSMIC	VLSST	DEG_SPOP_SBC_1	0.6936
p.R485Q	SIDM01105	Melanoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.7329
p.R485Q	SIDM01433	Kidney Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	0.7329
p.R485Q	SK-MEL-3	skin	COSMIC	VLSST	DEG_SPOP_SBC_1	0.7329
p.N492Y	NCI-H64	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.1667
p.N492Y	NCI-H1436	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	0.1667
p.N495K	HDQ-P1	breast	COSMIC	VLSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons