DegronMD

Uniprot ID: P18848

Source protein: Cyclic AMP-dependent transcription factor ATF-4

Source gene: ATF4

Class: DEG_SPOP_SBC_1

Location: 169:173

E3 ligase: SPOP

DEGRON score: 0.9689

ASA_SCORE: 66.72

COIL: 0.8826

CONS_SCORE: 0.5892

DSS_SCORE: 0.4023

HELIX: 0.0344

FCONS_SCORE: 1.0043

RIG_SCORE: 0.6295

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171T	TCGA-AX-A2H2	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.6005
p.S171T	DO41959	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.6005
p.L170M	TCGA-D1-A177	UCEC	TCGA	VLSST	DEG_SPOP_SBC_1	0.5999
p.L170M	DO42528	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	0.5999
p.Q161L	DO222586	ESCA	ICGC	VLSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SPOP_SBC_1	169:173	VLSST	SPOP	0.9689	More...
Q14940	Sodium/hydrogen exchanger 5	DEG_SPOP_SBC_1	546:550	VLSST	SPOP	0.6553	More...
Q16890	Tumor protein D53	DEG_SPOP_SBC_1	178:182	VLSST	SPOP	0.9655	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	623:627	VLSST	SPOP	0.8694	More...
Q8NI08	Nuclear receptor coactivator 7	DEG_SPOP_SBC_1	206:210	VLSST	SPOP	0.9703	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	482:486	VLSST	SPOP	0.999	More...
Q9NS87	Kinesin-like protein KIF15	DEG_SPOP_SBC_1	53:57	VLSST	SPOP	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons