DegronMD - Q99081(TCF12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L480F	TCGA-2W-A8YY	CESC	TCGA	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2778
p.L480F	TCGA-2W-A8YY	CESC	TCGA	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1389
p.P367H	TCGA-66-2744	LUSC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.3056
p.L370I	TCGA-A5-A1OF	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.2222
p.R494W	TCGA-AA-A022	COAD	TCGA	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.R494W	TCGA-AA-A022	COAD	TCGA	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.25
p.T352A	TCGA-AP-A0LM	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.1111
p.T352A	DO43306	UCEC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.1111
p.Q375R	TCGA-AP-A1DK	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.0833
p.Q375R	TCGA-D1-A1NU	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.0833
p.S368L	TCGA-D3-A2JA	SKCM	TCGA	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.2778
p.S368L	DO47652	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.2778
p.S488L	TCGA-D3-A8GI	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.7667
p.R494L	TCGA-EE-A184	SKCM	TCGA	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.R494L	TCGA-EE-A184	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.25
p.G476A	TCGA-XF-A9SK	BLCA	TCGA	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1667
p.Q476E	DO461	BLCA	ICGC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1667
p.R489I	DO18056	KIRC	ICGC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.8102
p.H350Q	DO21643	LAML	ICGC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.0556
p.H350Q	DO21749	LAML	ICGC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.0556
p.L472R	DO50864	LICA	ICGC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0556
p.L472F	DO220890	MELA	ICGC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0556
p.L474I	DO43682	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.A479V	DO41752	UCEC	ICGC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.A479V	DO41752	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1111
p.A479V	CW-2	large intestine	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.A479V	CW-2	large intestine	COSMIC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1111
p.A482V	SIDM00875	Breast Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.6936
p.A482V	ACH-000624	Breast Cancer	CCLE	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.6936
p.A482V	HCC1806	breast	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.6936
p.R485Q	SIDM01105	Melanoma	GDSC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7329
p.R485Q	SIDM01433	Kidney Carcinoma	GDSC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7329
p.R485Q	SK-MEL-3	skin	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7329
p.L370V	ACH-002046	Endometrial/Uterine Cancer	CCLE	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.2222
p.T370A	LN-18	central nervous system	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.2222
p.R353H	HEC-1	endometrium	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	360:366	Mutation rewiring degron network	0.1389
p.N492Y	NCI-H64	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1667
p.N492Y	NCI-H64	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.N492Y	NCI-H1436	lung	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1667
p.N492Y	NCI-H1436	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.N495K	HDQ-P1	breast	COSMIC	VLSST	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.0833
p.N495K	HDQ-P1	breast	COSMIC	VTTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2222

Kaplan plot for TCF12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF12

UniProt ID: Q99081

Entrez ID: 6938

Protein name: Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF12 in