DegronMD

Uniprot ID: Q99081

Source protein: Transcription factor 12

Source gene: TCF12

Class: DEG_SCF_FBW7_1

Location: 360:366

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 70.4571

COIL: 0.937

CONS_SCORE: 0.5356

DSS_SCORE: 0.6746

HELIX: 0.0177

FCONS_SCORE: 1.1193

RIG_SCORE: 0.5174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P367H	TCGA-66-2744	LUSC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.3056
p.L370I	TCGA-A5-A1OF	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.2222
p.T352A	TCGA-AP-A0LM	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.1111
p.T352A	DO43306	UCEC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.1111
p.Q375R	TCGA-AP-A1DK	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.0833
p.Q375R	TCGA-D1-A1NU	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.0833
p.S368L	TCGA-D3-A2JA	SKCM	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.S368L	DO47652	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.H350Q	DO21643	LAML	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.0556
p.H350Q	DO21749	LAML	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.0556
p.L370V	ACH-002046	Endometrial/Uterine Cancer	CCLE	PSTPVGS	DEG_SCF_FBW7_1	0.2222
p.T370A	LN-18	central_nervous_system	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.2222
p.R353H	HEC-1	endometrium	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SCF_FBW7_1	345:351	PSTPVGS	FBXW7	0.9967	More...
P15923	Transcription factor E2-alpha	DEG_SCF_FBW7_1	353:359	PSTPVGS	FBXW7	0.9991	More...
Q99081	Transcription factor 12	DEG_SCF_FBW7_1	360:366	PSTPVGS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons