DegronMD

Uniprot ID: P15923

Source protein: Transcription factor E2-alpha

Source gene: TCF3

Class: DEG_SCF_FBW7_1

Location: 353:359

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 59.1286

COIL: 0.9486

CONS_SCORE: 0.5622

DSS_SCORE: 0.6225

HELIX: 0.0201

FCONS_SCORE: 1.249

RIG_SCORE: 0.5574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S359C	DO218535	BTCA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.8652
p.S359F	DO23356	LINC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.9093
p.G362D	SIDM01104	Melanoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.G362D	SIDM01111	Ewing's Sarcoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.S345L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.5556
p.S345L	ACH-000995	Leukemia	CCLE	PSTPVGS	DEG_SCF_FBW7_1	0.5556
p.S345L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.5556
p.P353L	ACH-001192	Bone Cancer	CCLE	PSTPVGS	DEG_SCF_FBW7_1	0.6471
p.D344N	TE-8	oesophagus	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SCF_FBW7_1	345:351	PSTPVGS	FBXW7	0.9967	More...
P15923	Transcription factor E2-alpha	DEG_SCF_FBW7_1	353:359	PSTPVGS	FBXW7	0.9991	More...
Q99081	Transcription factor 12	DEG_SCF_FBW7_1	360:366	PSTPVGS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons