DegronMD - P15884(TCF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L229F	TCGA-2Z-A9J3	KIRP	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.6981
p.G222V	TCGA-52-7809	LUSC	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.L344F	TCGA-75-6214	LUAD	TCGA	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.3056
p.S347C	TCGA-A2-A0CL	BRCA	TCGA	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation altering degron motif	0.7541
p.Q337H	TCGA-AX-A0J0	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1111
p.S354N	TCGA-AX-A0J1	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.S354N	SIDM00373	Endometrial Carcinoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.S354N	SNG-M	endometrium	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.S210L	TCGA-DA-A1HV	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7667
p.G209S	TCGA-EE-A2MU	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.6993
p.G230V	TCGA-ER-A19P	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7532
p.S200F	TCGA-FS-A1Z0	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1667
p.R259Q	TCGA-FS-A1ZZ	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P238T	TCGA-IB-7651	PAAD	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.G239R	TCGA-NK-A5CT	LUSC	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0833
p.G239R	TCGA-NK-A5CT	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.L228F	TCGA-YG-AA3N	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.6981
p.P348S	DO44042	BLCA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation altering degron motif	0.6752
p.H247Q	DO224662	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.S245C	DO2155	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.S340R	DO6308	CESC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1944
p.M217I	DO8360	COAD	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1389
p.M217I	DO8360	COAD	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0833
p.G237V	DO228627	GACA	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.G232A	DO233718	GACA	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.T359K	DO228974	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1111
p.N344K	DO229028	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.3056
p.N339K	DO229038	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1667
p.T210N	DO229006	LICA	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7055
p.S354P	DO52243	LIHC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.L242F	DO24830	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.N344S	DO45452	LUSC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.3056
p.P202S	DO220891	MELA	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.P202S	COLO-741	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.P259L	DO220902	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.S229H	DO222546	MELA	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7609
p.D197G	DO228138	PBCA	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.E261K	DO47281	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.G220S	DO37406	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.G220S	DO37406	SKCM	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.S203F	DO50297	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.25
p.S343L	DO50288	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.2778
p.S342L	DO47563	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.P199T	DO43154	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1389
p.S198L	DO52426	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.S252N	DO41199	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7069
p.S252N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7069
p.Q235H	DO41133	UCEC	ICGC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.S242T	SIDM00541	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S242T	HT55	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.G342E	SIDM00120	Prostate Carcinoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.P243R	SIDM00301	Pancreatic Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P243R	KP-4	pancreas	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.S353T	SIDM00225	Melanoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.2778
p.S353T	IST-MEL1	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.2778
p.G222S	SIDM01659	Kidney Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.L220F	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.L220F	SIDM01519	Head and Neck Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.L220V	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.L220V	SIDM01519	Head and Neck Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.G228R	ACH-000853	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7568
p.G228R	NCI-H661	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7568
p.P222S	ACH-001190	Skin Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.P222S	SK-MEL-2	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.S241L	ACH-002338	Skin Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.S241L	ACH-002510	Skin Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.P226L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7582
p.H222Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.S231N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.3056
p.P255A	NCI-H1869	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.P254A	NCI-H1869	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.3056
p.H356R	CCK-81	large intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1944
p.G218V	NCI-SNU-1	stomach	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.G218V	NCI-SNU-1	stomach	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.T213K	L-540	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.25
p.P352S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.3056
p.N343I	NCI-H211	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.2778
p.G236R	RPMI-2650	upper aerodigestive tract	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.S251T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6005
p.P224L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.G358R	NCI-H661	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1389
p.P232L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.T237K	L-540	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.S250N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7069
p.P202L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.2222
p.S249T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S228N	SNG-M	endometrium	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7069
p.G231V	NCI-SNU-1	stomach	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.3056
p.H338R	CCK-81	large intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1389
p.G198R	NCI-H661	lung	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.G242V	NCI-SNU-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.P254L	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.3056
p.P219L	SNU-1040	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.P219L	SNU-1040	large intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.H342Q	RKO	large intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.25
p.S227T	IST-MEL1	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7116
p.T255K	L-540	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.H238R	CCK-81	large intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.P237L	SNU-1040	large intestine	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.H228Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7582
p.S210N	SNG-M	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7069
p.H197Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.H210Q	RKO	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7582
p.P358S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1389
p.P237A	NCI-H1869	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.P200S	COLO-741	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1667
p.S227N	SNG-M	endometrium	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7069
p.N361D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.0556
p.R349L	DU-145	prostate	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation altering degron motif	0.8428
p.P208A	NCI-H1869	lung	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7503
p.S229N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7069
p.N211I	NCI-H211	lung	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.3056
p.H355Q	RKO	large intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.2222
p.H220Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0556
p.H220Q	huH-1	liver	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.P208L	SNU-1040	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7582
p.N229D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.6932
p.N356I	NCI-H211	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1944
p.S207N	TE-10	oesophagus	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7069
p.H198Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1111
p.T226K	L-540	haematopoietic and lymphoid tissue	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7306
p.P255L	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.P201L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.1944
p.D356V	NCC021	kidney	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.1944
p.G260V	NCI-SNU-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S258N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1944
p.S237N	TE-10	oesophagus	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.P350S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation altering degron motif	0.6752
p.P219A	NCI-H1869	lung	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation rewiring degron network	0.0833
p.P219A	NCI-H1869	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.P208S	COLO-741	large intestine	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.6752
p.R360W	HCT-15	large intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation rewiring degron network	0.0833
p.S226T	IST-MEL1	skin	COSMIC	PWSSS	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7116
p.S257T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.R345L	DU-145	prostate	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	345:351	Mutation altering degron motif	0.8428
p.S209T	IST-MEL1	skin	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.6005
p.S206N	TE-10	oesophagus	COSMIC	PATST	DEG_SPOP_SBC_1	206:210	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF4

UniProt ID: P15884

Entrez ID: 6925

Protein name: Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF4 in