DegronMD

Uniprot ID: P15884

Source protein: Transcription factor 4

Source gene: TCF4

Class: DEG_SPOP_SBC_1

Location: 206:210

E3 ligase: SPOP

DEGRON score: 0.9056

ASA_SCORE: 58.48

COIL: 0.8472

CONS_SCORE: 0.3285

DSS_SCORE: 0.5106

HELIX: 0.053

FCONS_SCORE: 0.9318

RIG_SCORE: 0.6302

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S210L	TCGA-DA-A1HV	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.7667
p.G209S	TCGA-EE-A2MU	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.6993
p.S200F	TCGA-FS-A1Z0	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.1667
p.M217I	DO8360	COAD	ICGC	PATST	DEG_SPOP_SBC_1	0.1389
p.T210N	DO229006	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.7055
p.P202S	DO220891	MELA	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.P202S	COLO-741	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.D197G	DO228138	PBCA	ICGC	PATST	DEG_SPOP_SBC_1	0.0833
p.G220S	DO37406	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.0556
p.S203F	DO50297	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.P199T	DO43154	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.1389
p.S198L	DO52426	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.L220F	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.0556
p.L220V	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.0556
p.G218V	NCI-SNU-1	stomach	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.T213K	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.25
p.P202L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.G198R	NCI-H661	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.P219L	SNU-1040	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.S210N	SNG-M	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	0.7069
p.H197Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.H210Q	RKO	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.7582
p.P200S	COLO-741	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.1667
p.P208A	NCI-H1869	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.7503
p.N211I	NCI-H211	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.3056
p.H220Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	0.0556
p.P208L	SNU-1040	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.7582
p.S207N	TE-10	oesophagus	COSMIC	PATST	DEG_SPOP_SBC_1	0.7069
p.H198Q	huH-1	liver	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.P201L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1944
p.P219A	NCI-H1869	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.P208S	COLO-741	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.6752
p.S209T	IST-MEL1	skin	COSMIC	PATST	DEG_SPOP_SBC_1	0.6005
p.S206N	TE-10	oesophagus	COSMIC	PATST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with TCF4 mutations

All proteins holding degron of PATST