DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 4466:4470

E3 ligase: SPOP

DEGRON score: 0.9678

ASA_SCORE: 88.08

COIL: 0.9116

CONS_SCORE: 0

DSS_SCORE: 0.4703

HELIX: 0.0296

FCONS_SCORE: 0

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4465H	TCGA-17-Z020	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.3056
p.P4465H	TCGA-AX-A1C5	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.3056
p.P4465H	DO41422	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.3056
p.G4473R	TCGA-75-5126	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.G4473R	DO23711	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.P4479T	TCGA-CC-A8HS	LIHC	TCGA	PATST	DEG_SPOP_SBC_1	0.0833
p.P4479T	DO52186	LIHC	ICGC	PATST	DEG_SPOP_SBC_1	0.0833
p.V4480I	TCGA-DU-6392	LGG	TCGA	PATST	DEG_SPOP_SBC_1	0.0556
p.V4480I	DO22237	LGG	ICGC	PATST	DEG_SPOP_SBC_1	0.0556
p.T4463I	TCGA-EE-A3JD	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.T4463I	DO50299	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.L4460M	TCGA-L5-A4OJ	ESCA	TCGA	PATST	DEG_SPOP_SBC_1	0.1667
p.L4460M	DO52661	MALY	ICGC	PATST	DEG_SPOP_SBC_1	0.1667
p.P4458L	DO229010	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458L	DO229016	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458L	DO229005	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458L	DO234285	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458L	DO52365	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.I4464K	DO228555	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.P4458T	SIDM00770	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458T	ACH-000559	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1111
p.P4458T	NCI-H1836	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.S4477P	SIDM00969	Ovarian Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1389
p.S4477P	SIDM00583	Pancreatic Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1389
p.S4477P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1389
p.V4480A	SIDM00217	Colorectal Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.0556
p.V4480A	ACH-000999	Colon/Colorectal Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.0556
p.V4480A	SNU-1040	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PATST