DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: DEG_SPOP_SBC_1

Location: 525:529

E3 ligase: SPOP

DEGRON score: 0.9883

ASA_SCORE: 76.76

COIL: 0.8738

CONS_SCORE: 0.4053

DSS_SCORE: 0.5639

HELIX: 0.1068

FCONS_SCORE: 1.0361

RIG_SCORE: 0.6614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P525L	TCGA-55-6642	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.7582
p.T527A	TCGA-56-A49D	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	0.7139
p.R523I	DO229037	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.T528A	DO45475	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.S537P	SIDM00845	Burkitt's Lymphoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1111
p.S537P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1111
p.S537P	SIDM00461	Acute Myeloid Leukemia	GDSC	PATST	DEG_SPOP_SBC_1	0.1111
p.S537P	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1111
p.S537P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.S537P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1111
p.S538P	ACH-000037	Sarcoma	CCLE	PATST	DEG_SPOP_SBC_1	0.0833
p.S538P	ACH-000786	Lymphoma	CCLE	PATST	DEG_SPOP_SBC_1	0.0833
p.S538P	ACH-000992	Head and Neck Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.0833
p.S538P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.S538P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.T537A	ACH-000996	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1111
p.S530P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.3056
p.S530P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.3056
p.S530P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with ZC3H12C mutations

All proteins holding degron of PATST