DegronMD

Uniprot ID: P38935

Source protein: DNA-binding protein SMUBP-2

Source gene: IGHMBP2

Class: DEG_SPOP_SBC_1

Location: 669:673

E3 ligase: SPOP

DEGRON score: 0.9876

ASA_SCORE: 87.68

COIL: 0.94

CONS_SCORE: 0.356

DSS_SCORE: 0.8342

HELIX: 0.0258

FCONS_SCORE: 1.0054

RIG_SCORE: 0.5502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q678H	TCGA-AP-A1DK	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.1944
p.Q678H	DO42033	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.1944
p.R679W	TCGA-BG-A0LX	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.1667
p.R679W	DO41919	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.1667
p.S677G	TCGA-BR-6454	STAD	TCGA	PATST	DEG_SPOP_SBC_1	0.6667
p.S677G	DO38595	STAD	ICGC	PATST	DEG_SPOP_SBC_1	0.6667
p.T671A	DO223837	AML	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO221233	AML	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO229010	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO229003	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO229005	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO234205	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO229346	LAML	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO229489	LAML	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO52365	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO231007	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.T671A	DO220917	WT	ICGC	PATST	DEG_SPOP_SBC_1	0.7139
p.G682E	DO233107	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.0833
p.R679Q	DO233737	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.1667
p.R679L	DO229045	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with IGHMBP2 mutations

All proteins holding degron of PATST