DegronMD

Uniprot ID: Q96Q05

Source protein: Trafficking protein particle complex subunit 9

Source gene: TRAPPC9

Class: DEG_SPOP_SBC_1

Location: 897:901

E3 ligase: SPOP

DEGRON score: 0.7829

ASA_SCORE: 73.92

COIL: 0.8494

CONS_SCORE: 0.3511

DSS_SCORE: 0.1103

HELIX: 0.0674

FCONS_SCORE: 0.8029

RIG_SCORE: 0.7761

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C898F	TCGA-44-6777	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.7108
p.C898F	TCGA-78-8662	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.7108
p.E900D	TCGA-AP-A1DV	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.6758
p.E900D	TCGA-D1-A103	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.6758
p.P897S	SW684	soft_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.6752
p.L894M	TCGA-B5-A1MX	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.S894N	ACH-000642	Non-Cancerous	CCLE	PATST	DEG_SPOP_SBC_1	0.25
p.E906K	DO10340	COAD	ICGC	PATST	DEG_SPOP_SBC_1	0.1944
p.L906F	SIDM00383	Gastric Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1944
p.L906F	ACH-002198	Gastric Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1944
p.L906F	SCH	stomach	COSMIC	PATST	DEG_SPOP_SBC_1	0.1944

Showing 1 to 11 of 11 entries

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Drug responses associated with TRAPPC9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of PATST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...

Showing 1 to 20 of 20 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with TRAPPC9 mutations

All proteins holding degron of PATST