DegronMD

Uniprot ID: Q04637

Source protein: Eukaryotic translation initiation factor 4 gamma 1

Source gene: EIF4G1

Class: DEG_SPOP_SBC_1

Location: 1115:1119

E3 ligase: SPOP

DEGRON score: 0.9995

ASA_SCORE: 76.74

COIL: 0.8592

CONS_SCORE: 0.336

DSS_SCORE: 0.5545

HELIX: 0.1134

FCONS_SCORE: 1.0028

RIG_SCORE: 0.6868

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1109R	TCGA-AB-2833	LAML	TCGA	PATST	DEG_SPOP_SBC_1	0.1667
p.R1129H	TCGA-AX-A2HD	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.0556
p.R1129H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PATST	DEG_SPOP_SBC_1	0.0556
p.P1112H	TCGA-BR-8361	STAD	TCGA	PATST	DEG_SPOP_SBC_1	0.25
p.A1115T	TCGA-UF-A7JS	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	0.7139
p.G1112D	DO575	BLCA	ICGC	PATST	DEG_SPOP_SBC_1	0.25
p.R1109Q	DO52495	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.1667
p.G1128R	DO234401	ESAD	ICGC	PATST	DEG_SPOP_SBC_1	0.0833
p.R1127L	DO229029	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.R1121P	DO49876	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.R1121S	DO28923	OV	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.A1115D	DO229275	THCA	ICGC	PATST	DEG_SPOP_SBC_1	0.7793
p.R1127Q	DO42280	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.1111
p.E1113K	DO43186	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.E1113K	DO42608	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.D1117N	DO41331	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.6932
p.D1117N	NCI-H838	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.6932
p.R1121H	SIDM00844	Burkitt's Lymphoma	GDSC	PATST	DEG_SPOP_SBC_1	0.2778
p.R1110Q	ACH-000641	Leukemia	CCLE	PATST	DEG_SPOP_SBC_1	0.6389
p.R1110Q	ACH-001036	Leukemia	CCLE	PATST	DEG_SPOP_SBC_1	0.6389
p.R1110Q	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.6389
p.T1124M	ACH-000961	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1944
p.L1111H	LCLC-97TM1	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.D1116N	NCI-H838	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.6932
p.R1118Q	TK10	kidney	COSMIC	PATST	DEG_SPOP_SBC_1	0.7329
p.R1118H	SNU-1040	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.8244
p.S1121F	SNU-175	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.2778
p.L1112H	LCLC-97TM1	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.25
p.R1119H	SNU-1040	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.8244
p.S1122F	SNU-175	large_intestine	COSMIC	PATST	DEG_SPOP_SBC_1	0.25
p.R1111Q	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.R1117Q	TK10	kidney	COSMIC	PATST	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with EIF4G1 mutations

All proteins holding degron of PATST