DegronMD - Q86UE4(MTDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P514L	TCGA-85-8481	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7582
p.P514L	DO45465	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7582
p.D218H	TCGA-AA-3511	COAD	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.6577
p.D218H	DO7804	COAD	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.6577
p.P520S	TCGA-B5-A11E	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.P520S	DO41644	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.T220I	TCGA-B5-A1MX	UCEC	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.3056
p.T220I	DO41999	UCEC	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.3056
p.R207C	TCGA-CG-4306	STAD	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1667
p.R207C	DO38567	STAD	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1667
p.Q507H	TCGA-CR-7402	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.Q507H	DO15727	HNSC	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.S521Y	TCGA-DU-6392	LGG	TCGA	PATST	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.6944
p.S521Y	DO22237	LGG	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation blocking phosphorylation signal	0.6944
p.S214C	TCGA-JW-A5VL	CESC	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.8652
p.S214C	DO49976	CESC	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.8652
p.S525L	TCGA-NJ-A55R	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.S525L	DO218947	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.P508H	DO222755	COCA	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.D213N	DO233160	GACA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.6932
p.G215C	DO229019	LICA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.76
p.V522L	DO229028	LICA	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.A515S	DO229038	LICA	ICGC	PATST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.6477
p.S219L	DO222875	MELA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation altering degron motif	0.7667
p.T220A	DO234133	THCA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.3056
p.T227I	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	SIDM01519	Head and Neck Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	S-117	soft tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.T227I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.R205H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.R205H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.I228V	SIDM00251	Gastric Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.I228V	TGBC11TKB	stomach	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.I224T	SIDM00537	Colorectal Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1944
p.I224T	GP5d	large intestine	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1944
p.T204I	ACH-000037	Sarcoma	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.T204I	ACH-000786	Lymphoma	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.T204I	ACH-000992	Head and Neck Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.T204I	ACH-001067	Brain Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.T204I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.T204I	S-117	soft tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.0833
p.R523S	ACH-000549	Head and Neck Cancer	CCLE	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1944
p.A522V	ACH-000866	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.A522V	NCI-H1048	lung	COSMIC	PATST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.I205V	ACH-000949	Gastric Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111
p.I205V	TGBC11TKB	stomach	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	213:219	Mutation rewiring degron network	0.1111

Kaplan plot for MTDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTDH

UniProt ID: Q86UE4

Entrez ID: 92140

Protein name: Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTDH in