DegronMD

Uniprot ID: Q86UE4

Source protein: Protein LYRIC

Source gene: MTDH

Class: DEG_SCF_TRCP1_1

Location: 213:219

E3 ligase: BTRC

DEGRON score: 0.9949

ASA_SCORE: 82.9286

COIL: 0.9149

CONS_SCORE: 0.5524

DSS_SCORE: 0.489

HELIX: 0.0651

FCONS_SCORE: 0.8203

RIG_SCORE: 0.6782

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D218H	TCGA-AA-3511	COAD	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	0.6577
p.D218H	DO7804	COAD	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.6577
p.T220I	TCGA-B5-A1MX	UCEC	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	0.3056
p.T220I	DO41999	UCEC	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.3056
p.R207C	TCGA-CG-4306	STAD	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	0.1667
p.R207C	DO38567	STAD	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.1667
p.S214C	TCGA-JW-A5VL	CESC	TCGA	DSGSLDS	DEG_SCF_TRCP1_1	0.8652
p.S214C	DO49976	CESC	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.8652
p.D213N	DO233160	GACA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.6932
p.G215C	DO229019	LICA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.76
p.S219L	DO222875	MELA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.7667
p.T220A	DO234133	THCA	ICGC	DSGSLDS	DEG_SCF_TRCP1_1	0.3056
p.T227I	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	SIDM01519	Head and Neck Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	S-117	soft_tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.T227I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.R205H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.R205H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.I228V	SIDM00251	Gastric Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.I228V	TGBC11TKB	stomach	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.I224T	SIDM00537	Colorectal Carcinoma	GDSC	DSGSLDS	DEG_SCF_TRCP1_1	0.1944
p.I224T	GP5d	large_intestine	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.1944
p.T204I	ACH-000037	Sarcoma	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.T204I	ACH-000786	Lymphoma	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.T204I	ACH-000992	Head and Neck Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.T204I	ACH-001067	Brain Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.T204I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.T204I	S-117	soft_tissue	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.0833
p.I205V	ACH-000949	Gastric Cancer	CCLE	DSGSLDS	DEG_SCF_TRCP1_1	0.1111
p.I205V	TGBC11TKB	stomach	COSMIC	DSGSLDS	DEG_SCF_TRCP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSLDS

Degron related mutations and impact score

Drug responses associated with MTDH mutations

All proteins holding degron of DSGSLDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UE4	Protein LYRIC	DEG_SCF_TRCP1_1	213:219	DSGSLDS	BTRC	0.9949	More...