DegronMD

Uniprot ID: Q86UE4

Source protein: Protein LYRIC

Source gene: MTDH

Class: DEG_SPOP_SBC_1

Location: 514:518

E3 ligase: SPOP

DEGRON score: 0.987

ASA_SCORE: 90.18

COIL: 0.95

CONS_SCORE: 0.4523

DSS_SCORE: 0.5649

HELIX: 0.0252

FCONS_SCORE: 0.9159

RIG_SCORE: 0.6516

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P514L	TCGA-85-8481	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	0.7582
p.P514L	DO45465	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	0.7582
p.S521Y	TCGA-DU-6392	LGG	TCGA	PATST	DEG_SPOP_SBC_1	0.6944
p.S521Y	DO22237	LGG	ICGC	PATST	DEG_SPOP_SBC_1	0.6944
p.A515S	DO229038	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.6477
p.P520S	TCGA-B5-A11E	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	0.2778
p.P520S	DO41644	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.V522L	DO229028	LICA	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.A522V	ACH-000866	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.2222
p.A522V	NCI-H1048	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.2222
p.R523S	ACH-000549	Head and Neck Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1944
p.P508H	DO222755	COCA	ICGC	PATST	DEG_SPOP_SBC_1	0.1667
p.Q507H	TCGA-CR-7402	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	0.1389
p.Q507H	DO15727	HNSC	ICGC	PATST	DEG_SPOP_SBC_1	0.1389
p.S525L	TCGA-NJ-A55R	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.1389
p.S525L	DO218947	LUAD	ICGC	PATST	DEG_SPOP_SBC_1	0.1389

Showing 1 to 16 of 16 entries

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Drug responses associated with MTDH mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PATST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...

Showing 1 to 20 of 20 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with MTDH mutations

All proteins holding degron of PATST