DegronMD

Uniprot ID: P15336

Source protein: Cyclic AMP-dependent transcription factor ATF-2

Source gene: ATF2

Class: DEG_SPOP_SBC_1

Location: 318:322

E3 ligase: SPOP

DEGRON score: 0.9918

ASA_SCORE: 87.16

COIL: 0.9416

CONS_SCORE: 0.339

DSS_SCORE: 0.879

HELIX: 0.043

FCONS_SCORE: 1.0104

RIG_SCORE: 0.5692

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E308Q	TCGA-39-5016	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	0.0556
p.S321F	TCGA-95-A4VK	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	0.9093
p.P312L	TCGA-AA-3496	COAD	TCGA	PATST	DEG_SPOP_SBC_1	0.1667
p.Q316K	TCGA-AA-3848	COAD	TCGA	PATST	DEG_SPOP_SBC_1	0.2778
p.P326S	TCGA-D6-6516	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	0.2222
p.S310F	TCGA-EE-A2GS	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	0.5556
p.D320N	DO2401	BRCA	ICGC	PATST	DEG_SPOP_SBC_1	0.6932
p.S326P	DO233145	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.2222
p.A316S	DO233884	GACA	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.S321G	DO33043	PACA	ICGC	PATST	DEG_SPOP_SBC_1	0.8104
p.P328Q	DO35345	PACA	ICGC	PATST	DEG_SPOP_SBC_1	0.6111
p.P328Q	DO47623	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.6111
p.D324H	DO232462	PBCA	ICGC	PATST	DEG_SPOP_SBC_1	0.2778
p.S322L	DO37406	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	0.7667
p.K309N	DO41020	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	0.0833
p.R311Q	SIDM00454	Rhabdomyosarcoma	GDSC	PATST	DEG_SPOP_SBC_1	0.1389
p.R311Q	ACH-000689	Sarcoma	CCLE	PATST	DEG_SPOP_SBC_1	0.1389
p.R311Q	RH-18	soft_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1389
p.P326L	SIDM01132	Other Solid Cancers	GDSC	PATST	DEG_SPOP_SBC_1	0.2222
p.H331L	SIDM00730	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.0833
p.H331L	ACH-000610	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.0833
p.H331L	NCI-H2227	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.0833
p.A319D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	0.6682
p.A319D	ACH-000851	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.6682
p.A330G	ACH-000870	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	0.1111
p.H313L	NCI-H2227	lung	COSMIC	PATST	DEG_SPOP_SBC_1	0.1944
p.D317H	VM-CUB-1	urinary_tract	COSMIC	PATST	DEG_SPOP_SBC_1	0.3056
p.R324H	SK-UT-1	soft_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.2778
p.R324H	IGROV-1	ovary	COSMIC	PATST	DEG_SPOP_SBC_1	0.2778
p.G312S	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SPOP_SBC_1	170:174	PATST	SPOP	0.9982	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	318:322	PATST	SPOP	0.9918	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	206:210	PATST	SPOP	0.9056	More...
P20719	Homeobox protein Hox-A5	DEG_SPOP_SBC_1	89:93	PATST	SPOP	0.973	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	50:54	PATST	SPOP	0.9962	More...
P38935	DNA-binding protein SMUBP-2	DEG_SPOP_SBC_1	669:673	PATST	SPOP	0.9876	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	71:75	PATST	SPOP	0.9475	More...
Q04637	Eukaryotic translation initiation factor 4 gamma 1	DEG_SPOP_SBC_1	1115:1119	PATST	SPOP	0.9995	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SPOP_SBC_1	575:579	PATST	SPOP	0.999	More...
Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	DEG_SPOP_SBC_1	1002:1006	PATST	SPOP	0.9965	More...
Q86UE4	Protein LYRIC	DEG_SPOP_SBC_1	514:518	PATST	SPOP	0.987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4466:4470	PATST	SPOP	0.9678	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12043:12047	PATST	SPOP	0.7282	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	860:864	PATST	SPOP	0.9349	More...
Q96Q05	Trafficking protein particle complex subunit 9	DEG_SPOP_SBC_1	897:901	PATST	SPOP	0.7829	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	829:833	PATST	SPOP	0.9954	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	1438:1442	PATST	SPOP	0.9888	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	525:529	PATST	SPOP	0.9883	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	110:114	PATST	SPOP	0.6991	More...
E7ERA6	RING finger protein 223	DEG_SPOP_SBC_1	234:238	PATST	SPOP	0.7877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATST

Degron related mutations and impact score

Drug responses associated with ATF2 mutations

All proteins holding degron of PATST