DegronMD - P15336(ATF2)

GO - Biological processes (BP): abducens nucleus development [GO:0021742]; adipose tissue development [GO:0060612]; amelogenesis [GO:0097186]; apoptotic process involved in development [GO:1902742]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; cellular lipid metabolic process [GO:0044255]; cellular response to anisomycin [GO:0072740]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; detection of cell density [GO:0060245]; facial nucleus development [GO:0021754]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; hematopoietic progenitor cell differentiation [GO:0002244]; hepatocyte apoptotic process [GO:0097284]; histone H2B acetylation [GO:0043969]; histone H4 acetylation [GO:0043967]; hypoglossal nucleus development [GO:0021743]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; in utero embryonic development [GO:0001701]; JNK cascade [GO:0007254]; liver development [GO:0001889]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; motor neuron apoptotic process [GO:0097049]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurofilament cytoskeleton organization [GO:0060052]; NK T cell differentiation [GO:0001865]; outflow tract morphogenesis [GO:0003151]; p38MAPK cascade [GO:0038066]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein import into nucleus [GO:0006606]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; response to osmotic stress [GO:0006970]; response to water deprivation [GO:0009414]; vacuole organization [GO:0007033]; white fat cell differentiation [GO:0050872] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R206M	TCGA-19-1787	GBM	TCGA	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.R206M	TCGA-AX-A063	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.R206M	TCGA-D3-A2JC	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.D135N	TCGA-2W-A8YY	CESC	TCGA	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.E308Q	TCGA-39-5016	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0556
p.E148K	TCGA-44-2665	LUAD	TCGA	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.S321F	TCGA-95-A4VK	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.9093
p.A201S	TCGA-A5-A1OF	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1944
p.P312L	TCGA-AA-3496	COAD	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.Q316K	TCGA-AA-3848	COAD	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.Q453H	TCGA-AP-A0LM	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.Q453H	TCGA-E6-A1LX	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.S136N	TCGA-B5-A3FA	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	141:145	Mutation blocking phosphorylation signal	0.6389
p.S456L	TCGA-CA-6718	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1389
p.P326S	TCGA-D6-6516	HNSC	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.S310F	TCGA-EE-A2GS	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	318:322	Mutation blocking phosphorylation signal	0.5556
p.A471V	TCGA-XK-AAIW	PRAD	TCGA	VSSTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.D320N	DO2401	BRCA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.6932
p.Q140H	DO4563	BRCA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.3056
p.Q200K	DO9740	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.V142F	DO9812	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7068
p.P196L	DO9570	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7582
p.S326P	DO233145	GACA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.A316S	DO233884	GACA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.R148M	DO13522	GBM	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.R148M	DO47578	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.R148M	DO42201	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.S192L	DO10880	GBM	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7667
p.P134Q	DO228900	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.N187K	DO228976	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1944
p.A143E	DO229019	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7701
p.T189N	DO229022	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.A203D	DO229036	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1389
p.P196Q	DO229038	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7035
p.T138N	DO229041	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.P151H	DO229045	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.P184Q	DO229009	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.V182M	DO45035	LINC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.S205F	DO45360	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.E192Q	DO26701	LUSC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.6744
p.S321G	DO33043	PACA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.8104
p.P328Q	DO35345	PACA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation blocking phosphorylation signal	0.6111
p.P328Q	DO47623	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation blocking phosphorylation signal	0.6111
p.R147H	DO228176	PBCA	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2778
p.D324H	DO232462	PBCA	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.R188S	DO51423	PRAD	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.G144E	DO37679	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7199
p.S322L	DO37406	SKCM	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7667
p.S194F	DO37465	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7982
p.I190N	DO43434	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2778
p.A186T	DO43306	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1667
p.Q206H	DO42312	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.K309N	DO41020	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.A183S	DO42568	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.P151S	DO41361	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.R311Q	SIDM00454	Rhabdomyosarcoma	GDSC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.R311Q	ACH-000689	Sarcoma	CCLE	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.R311Q	RH-18	soft tissue	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.V183A	SIDM00680	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.V183A	ACH-000957	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.V183A	LS-180	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.P326L	SIDM01132	Other Solid Cancers	GDSC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2222
p.H331L	SIDM00730	Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.H331L	ACH-000610	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.H331L	NCI-H2227	lung	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.0833
p.Q134H	SIDM00927	Small Cell Lung Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.Q134H	ACH-000871	Lung Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.Q134H	NCI-H510A	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.N205S	SIDM00217	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.N205S	ACH-000999	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.N205S	SNU-1040	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0833
p.A319D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.6682
p.A319D	ACH-000851	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.6682
p.A330G	ACH-000870	Lung Cancer	CCLE	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.V142I	NCI-H596	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.7076
p.H313L	NCI-H2227	lung	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1944
p.S191L	MCC26	skin	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.3056
p.S149F	NCI-H2009	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation substituting flanking lysine	0.3333
p.E184Q	NCI-H1568	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.N147S	SNU-1040	large intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2778
p.H155L	NCI-H2227	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0556
p.V200I	NCI-H596	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.D317H	VM-CUB-1	urinary tract	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.3056
p.R135Q	RH-18	soft tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.R324H	SK-UT-1	soft tissue	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.R324H	IGROV-1	ovary	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.2778
p.N187S	SNU-1040	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1944
p.R195Q	RH-18	soft tissue	COSMIC	PTSST	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7329
p.G312S	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1667
p.S131L	MCC26	skin	COSMIC	PESTT	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0556

Kaplan plot for ATF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF2

UniProt ID: P15336

Entrez ID: 1386

Protein name: Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATF2 in