DegronMD

Uniprot ID: P15336

Source protein: Cyclic AMP-dependent transcription factor ATF-2

Source gene: ATF2

Class: DEG_SPOP_SBC_1

Location: 141:145

E3 ligase: SPOP

DEGRON score: 0.838

ASA_SCORE: 84.88

COIL: 0.9052

CONS_SCORE: 0.4179

DSS_SCORE: 0.8005

HELIX: 0.054

FCONS_SCORE: 1.1708

RIG_SCORE: 0.5862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D135N	TCGA-2W-A8YY	CESC	TCGA	PESTT	DEG_SPOP_SBC_1	0.1667
p.E148K	TCGA-44-2665	LUAD	TCGA	PESTT	DEG_SPOP_SBC_1	0.25
p.S136N	TCGA-B5-A3FA	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	0.6389
p.Q140H	DO4563	BRCA	ICGC	PESTT	DEG_SPOP_SBC_1	0.3056
p.V142F	DO9812	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.7068
p.R148M	DO13522	GBM	ICGC	PESTT	DEG_SPOP_SBC_1	0.25
p.R148M	DO47578	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	0.25
p.R148M	DO42201	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	0.25
p.P134Q	DO228900	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.1389
p.A143E	DO229019	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.7701
p.T138N	DO229041	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.25
p.P151H	DO229045	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.1667
p.R147H	DO228176	PBCA	ICGC	PESTT	DEG_SPOP_SBC_1	0.2778
p.G144E	DO37679	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	0.7199
p.P151S	DO41361	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	0.1667
p.Q134H	SIDM00927	Small Cell Lung Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.1389
p.Q134H	ACH-000871	Lung Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	0.1389
p.Q134H	NCI-H510A	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1389
p.V142I	NCI-H596	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.7076
p.S149F	NCI-H2009	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.3333
p.N147S	SNU-1040	large_intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	0.2778
p.H155L	NCI-H2227	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.0556
p.R135Q	RH-18	soft_tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1667
p.S131L	MCC26	skin	COSMIC	PESTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons