DegronMD - Q70CQ4(USP31)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1129C	TCGA-55-A48X	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7541
p.S1129C	DO24048	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7541
p.P1324L	TCGA-60-2711	LUSC	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation rewiring degron network	0.3056
p.P1324L	DO48215	ESCA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation rewiring degron network	0.3056
p.P1324L	DO26987	LUSC	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation rewiring degron network	0.3056
p.G1193W	TCGA-69-7974	LUAD	TCGA	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.25
p.G1193W	DO23850	LUAD	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.25
p.R1139W	TCGA-99-8028	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.R1139W	DO23561	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.R1025G	TCGA-A6-5666	COAD	TCGA	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.R1025G	DO9482	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.S770L	TCGA-AC-A23H	BRCA	TCGA	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1111
p.S770L	DO2401	BRCA	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1111
p.K216N	TCGA-AP-A056	UCEC	TCGA	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation substituting flanking lysine	0.1944
p.K216N	DO43971	UCEC	ICGC	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation substituting flanking lysine	0.1944
p.K216N	SIDM00590	Oral Cavity Carcinoma	GDSC	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation substituting flanking lysine	0.1944
p.K216N	HSC-2	upper aerodigestive tract	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation substituting flanking lysine	0.1944
p.Q1115H	TCGA-AP-A059	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.Q1115H	DO48366	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.Q1115H	DO41361	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.E820D	TCGA-AP-A0LM	UCEC	TCGA	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.2222
p.E820D	DO43306	UCEC	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.2222
p.S1208I	TCGA-BR-6452	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5556
p.S1208I	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5556
p.E1020D	TCGA-BS-A0UV	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation altering degron motif	0.5647
p.E1020D	DO42793	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation altering degron motif	0.5647
p.P1070S	TCGA-D3-A51R	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1389
p.P1070S	DO47480	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1389
p.R1205C	TCGA-D7-A747	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.1944
p.R1205C	DO51735	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.1944
p.S1117L	TCGA-DK-A6B6	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.S1117L	DO48576	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.S783F	TCGA-E5-A2PC	BLCA	TCGA	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.3056
p.S783F	DO702	BLCA	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.3056
p.S783F	DO220851	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.3056
p.S1178F	TCGA-EB-A3XB	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation blocking phosphorylation signal	0.6667
p.S1178F	DO228012	SKCA	ICGC	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation blocking phosphorylation signal	0.6667
p.S1178F	DO37856	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation blocking phosphorylation signal	0.6667
p.P769S	TCGA-EB-A3Y7	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.P769S	DO37499	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.S1067F	TCGA-EB-A431	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.0556
p.S1067F	DO37671	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.0556
p.P1179L	TCGA-EE-A20F	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.1944
p.P1179L	DO37961	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.1944
p.P1321L	TCGA-EE-A29C	SKCM	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation altering degron motif	0.6471
p.P1321L	DO222727	MELA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation altering degron motif	0.6471
p.P1321L	DO38028	SKCM	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation altering degron motif	0.6471
p.R1086Q	TCGA-EE-A2MR	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.R1086Q	DO23356	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.R1086Q	DO37819	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.G1164D	TCGA-EO-A22R	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.1667
p.G1164D	DO42713	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.1667
p.R792Q	TCGA-EO-A22U	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792Q	DO43755	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792Q	ACH-001738	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.S1199F	TCGA-FW-A3R5	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.7982
p.S1199F	DO37406	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.7982
p.S784F	TCGA-FW-A3R5	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.S784F	DO37406	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.P1321S	TCGA-FW-A5DY	SKCM	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation altering degron motif	0.5641
p.P1321S	DO47257	SKCM	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation altering degron motif	0.5641
p.Q1115R	TCGA-HD-8224	HNSC	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.Q1115R	DO15935	HNSC	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.G1083D	TCGA-HJ-7597	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.2778
p.G1083D	DO38195	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.2778
p.R1072C	TCGA-KK-A59V	PRAD	TCGA	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.R1072C	DO51346	PRAD	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.S1126F	TCGA-XF-A8HE	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7982
p.S1126F	DO49797	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation altering degron motif	0.7982
p.R1139S	TCGA-YL-A8SF	PRAD	TCGA	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.R1139S	DO51428	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0556
p.A1118T	DO228627	GACA	ICGC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1090T	DO233259	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.0833
p.L812M	DO233760	GACA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation altering degron motif	0.711
p.N1177S	DO233923	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	1170:1174	Mutation rewiring degron network	0.25
p.R1074S	DO228976	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.25
p.S1075R	DO228985	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.2778
p.S1075R	DO229037	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.2778
p.A799D	DO229018	LICA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.0833
p.R1190S	DO229040	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.1667
p.S814L	DO229052	LICA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation altering degron motif	0.7667
p.A1330S	DO229058	LICA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	1317:1323	Mutation rewiring degron network	0.1389
p.S803F	DO220912	MELA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.1944
p.P1090S	DO222418	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.0833
p.P1090S	ACH-000894	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.0833
p.S1208N	DO232224	PBCA	ICGC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5556
p.R792W	DO229453	SKCA	ICGC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792W	SIDM00602	Gastric Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792W	ACH-000919	Gastric Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792W	IM-95	stomach	COSMIC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.P1136L	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM00367	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM00281	Other Solid Cancers	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM00040	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM01217	Other Blood Cancers	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SIDM01582	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	DJM-1	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	TMK-1	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SBC-3	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	SLVL	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	TE-10	oesophagus	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	MY-M12	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.P1136L	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1389
p.R1086W	SIDM00935	Other Solid Cancers	GDSC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.R1086W	CAL-39	vulva	COSMIC	ADSSS	DEG_SPOP_SBC_1	1077:1081	Mutation rewiring degron network	0.1944
p.W789R	SIDM01090	Colorectal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.W789R	ACH-000943	Colon/Colorectal Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.W789R	RKO	large intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.S818F	SIDM01175	Other Sarcomas	GDSC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.2778
p.S818F	ACH-002309	Sarcoma	CCLE	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.2778
p.S818F	SW684	soft tissue	COSMIC	RRTSLASLS	DEG_APCC_DBOX_1	808:816	Mutation rewiring degron network	0.2778
p.A1137T	SIDM00789	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.A1137T	ACH-000997	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.A1137T	HCT-15	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1111
p.A1016T	SIDM01113	Other Sarcomas	GDSC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.25
p.A1016T	ACH-000939	Sarcoma	CCLE	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.25
p.A1016T	SK-UT-1	soft tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.25
p.A1120T	SIDM00251	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1944
p.A1120T	ACH-000949	Gastric Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1944
p.A1120T	TGBC11TKB	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.1944
p.P769L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.P769L	ACH-000785	Lung Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.P769L	NCI-H2126	lung	COSMIC	AGSTS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.L1015V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2222
p.L1015V	ACH-001738	Leukemia	CCLE	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2222
p.L1015V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2222
p.E1188D	SIDM01503	Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.1111
p.E1188D	ACH-000844	Lung Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.1111
p.T1138A	ACH-001031	Rhabdoid	CCLE	ASSTS	DEG_SPOP_SBC_1	1125:1129	Mutation rewiring degron network	0.0833
p.L193R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation rewiring degron network	0.1389
p.A1192T	ACH-001841	Bile Duct Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.2222
p.S207R	HCT-15	large intestine	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation altering degron motif	0.7427
p.S213G	ECC10	stomach	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	200:207	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP31

UniProt ID: Q70CQ4

Entrez ID: 57478

Protein name: Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP31 in