DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_SPOP_SBC_1

Location: 1196:1200

E3 ligase: SPOP

DEGRON score: 0.697

ASA_SCORE: 84.12

COIL: 0.607

CONS_SCORE: 0.2522

DSS_SCORE: 0.6978

HELIX: 0.265

FCONS_SCORE: 1.0239

RIG_SCORE: 0.6444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1193W	TCGA-69-7974	LUAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.G1193W	DO23850	LUAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.S1208I	TCGA-BR-6452	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.5556
p.S1208I	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5556
p.R1205C	TCGA-D7-A747	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1944
p.R1205C	DO51735	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1944
p.S1199F	TCGA-FW-A3R5	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7982
p.S1199F	DO37406	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7982
p.R1190S	DO229040	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.S1208N	DO232224	PBCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5556
p.E1188D	SIDM01503	Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.E1188D	ACH-000844	Lung Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.1111
p.A1192T	ACH-001841	Bile Duct Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons