DegronMD

Uniprot ID: Q86VV4

Source protein: Ran-binding protein 3-like

Source gene: RANBP3L

Class: DEG_SPOP_SBC_1

Location: 73:77

E3 ligase: SPOP

DEGRON score: 0.9807

ASA_SCORE: 82.62

COIL: 0.6758

CONS_SCORE: 0.2971

DSS_SCORE: 0.382

HELIX: 0.0586

FCONS_SCORE: 1.0866

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S85Y	TCGA-AX-A2HC	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1111
p.S85Y	DO41572	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.G67S	TCGA-D3-A51G	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G67S	DO47700	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.R74Q	TCGA-EO-A22U	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.6218
p.R74Q	DO43755	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.6218
p.R74Q	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.6218
p.R74Q	TE-4	oesophagus	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.6218
p.T70R	DO228471	BRCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO230334	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO229010	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO229013	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO229016	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO229003	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO229005	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.T70R	DO231036	LUSC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.R72S	DO229035	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.R74W	SIDM01617	Endometrial Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.7523

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons