DegronMD - Q6ZSJ9(SHISA6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P306L	TCGA-AX-A2HD	UCEC	TCGA	PPSY	ITCH	297:300	Mutation blocking phosphorylation signal	0.6111
p.P306L	DO233855	GACA	ICGC	PPSY	ITCH	297:300	Mutation blocking phosphorylation signal	0.6111
p.P306L	DO42608	UCEC	ICGC	PPSY	ITCH	297:300	Mutation blocking phosphorylation signal	0.6111
p.T261M	TCGA-B5-A3FA	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T261M	DO45299	LIRI	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T261M	DO52402	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T261M	SIDM00240	Cervical Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T261M	ACH-002180	Cervical Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T261M	OMC-1	cervix	COSMIC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.I238V	TCGA-D8-A1XQ	BRCA	TCGA	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0556
p.I238V	DO3095	BRCA	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0556
p.V248A	TCGA-EO-A3B0	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.V248A	DO219773	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.R260H	DO227990	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1111
p.R260H	DO223069	ESCA	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1111
p.R260H	DO233885	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1111
p.R302W	DO234350	ESAD	ICGC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2778
p.R302W	COLO-800	skin	COSMIC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2778
p.G293E	DO229453	SKCA	ICGC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2222
p.T308I	DO41361	UCEC	ICGC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.1111
p.Y303H	SIDM01090	Colorectal Carcinoma	GDSC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.25
p.Y303H	RKO	large intestine	COSMIC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.25
p.S252F	SIDM00652	Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.S252F	ACH-000780	Lung Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.S252F	NCI-H1105	lung	COSMIC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.S241Y	SIDM00282	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.S241Y	ACH-000998	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.S241Y	CW-2	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.R294K	SIDM00663	Melanoma	GDSC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.25
p.R294K	Hs939-T	skin	COSMIC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.25
p.T257S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation blocking phosphorylation signal	0.6389
p.T257S	H513	pleura	COSMIC	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation blocking phosphorylation signal	0.6389
p.T297N	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	297:300	Mutation altering degron motif	0.7055
p.T297N	CAL-12T	lung	COSMIC	PPSY	ITCH	297:300	Mutation altering degron motif	0.7055
p.I307L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.1389
p.I307L	KYSE-150	oesophagus	COSMIC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.1389
p.H295D	ACH-000886	Lung Cancer	CCLE	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2778
p.H295D	NCI-H2009	lung	COSMIC	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2778
p.P297S	ACH-000973	Bladder Cancer	CCLE	PPSY	ITCH	297:300	Mutation altering degron motif	0.6752
p.P297S	639-V	urinary tract	COSMIC	PPSY	ITCH	297:300	Mutation altering degron motif	0.6752
p.P247L	ACH-001786	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.3056
p.Q302H	ACH-002041	Thyroid Cancer	CCLE	PPSY	ITCH	297:300	Mutation rewiring degron network	0.2778
p.K300N	LS-411N	large intestine	COSMIC	PPSY	ITCH	297:300	Mutation altering degron motif	0.6918

Kaplan plot for SHISA6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHISA6

UniProt ID: Q6ZSJ9

Entrez ID: 388336

Protein name: Protein shisa-6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHISA6 in