DegronMD

Uniprot ID: Q6ZSJ9

Source protein: Protein shisa-6

Source gene: SHISA6

Class: DEG_SPOP_SBC_1

Location: 248:252

E3 ligase: SPOP

DEGRON score: 0.8915

ASA_SCORE: 76.98

COIL: 0.8772

CONS_SCORE: 0.6076

DSS_SCORE: 0.6985

HELIX: 0.0638

FCONS_SCORE: 0.9141

RIG_SCORE: 0.5927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T261M	TCGA-B5-A3FA	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T261M	DO45299	LIRI	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T261M	DO52402	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T261M	SIDM00240	Cervical Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T261M	ACH-002180	Cervical Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T261M	OMC-1	cervix	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.I238V	TCGA-D8-A1XQ	BRCA	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0556
p.I238V	DO3095	BRCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.V248A	TCGA-EO-A3B0	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.5825
p.V248A	DO219773	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5825
p.R260H	DO227990	COCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.R260H	DO223069	ESCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.R260H	DO233885	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.S252F	SIDM00652	Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.7982
p.S252F	ACH-000780	Lung Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.7982
p.S252F	NCI-H1105	lung	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.7982
p.S241Y	SIDM00282	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1389
p.S241Y	ACH-000998	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.1389
p.S241Y	CW-2	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.1389
p.T257S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.6389
p.T257S	H513	pleura	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.6389
p.P247L	ACH-001786	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons