DegronMD - Q5VVW2(GARNL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A949V	TCGA-A5-A0G1	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.3056
p.Q942R	TCGA-AA-3510	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.1111
p.R911S	TCGA-EE-A20F	SKCM	TCGA	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6316
p.G920V	TCGA-GV-A3JZ	BLCA	TCGA	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.25
p.S941T	TCGA-JY-A6FH	ESCA	TCGA	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0833
p.E948K	DO49964	CESC	ICGC	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.2778
p.Q920R	DO7783	COAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.25
p.P906S	DO8514	COAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.25
p.K901N	DO229045	LICA	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1111
p.P951S	DO38111	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation altering degron motif	0.6752
p.A964V	DO38427	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0556
p.K907T	DO48020	STAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.2778
p.A927V	DO42472	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.0556
p.R915W	DO41361	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.8634
p.R915W	DO41331	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.8634
p.T909A	SIDM00837	Colorectal Carcinoma	GDSC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6028
p.T909A	ACH-000958	Colon/Colorectal Cancer	CCLE	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6028
p.T909A	SW48	large intestine	COSMIC	TRRELLGLS	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6028
p.A964S	OVKATE	ovary	COSMIC	VRSSS	DEG_SPOP_SBC_1	950:954	Mutation rewiring degron network	0.0556

Kaplan plot for GARNL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GARNL3

UniProt ID: Q5VVW2

Entrez ID: 84253

Protein name: GTPase-activating Rap/Ran-GAP domain-like protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GARNL3 in