DegronMD

Uniprot ID: Q5VVW2

Source protein: GTPase-activating Rap/Ran-GAP domain-like protein 3

Source gene: GARNL3

Class: DEG_APCC_DBOX_1

Location: 909:917

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8113

ASA_SCORE: 81.8444

COIL: 0.4609

CONS_SCORE: 0.3246

DSS_SCORE: 0.5458

HELIX: 0.5187

FCONS_SCORE: 1.0862

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R911S	TCGA-EE-A20F	SKCM	TCGA	TRRELLGLS	DEG_APCC_DBOX_1	0.6316
p.G920V	TCGA-GV-A3JZ	BLCA	TCGA	TRRELLGLS	DEG_APCC_DBOX_1	0.25
p.Q920R	DO7783	COAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.25
p.P906S	DO8514	COAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.25
p.K901N	DO229045	LICA	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.1111
p.K907T	DO48020	STAD	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.2778
p.A927V	DO42472	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.0556
p.R915W	DO41361	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.8634
p.R915W	DO41331	UCEC	ICGC	TRRELLGLS	DEG_APCC_DBOX_1	0.8634
p.T909A	SIDM00837	Colorectal Carcinoma	GDSC	TRRELLGLS	DEG_APCC_DBOX_1	0.6028
p.T909A	ACH-000958	Colon/Colorectal Cancer	CCLE	TRRELLGLS	DEG_APCC_DBOX_1	0.6028
p.T909A	SW48	large_intestine	COSMIC	TRRELLGLS	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_APCC_DBOX_1	909:917	TRRELLGLS	APC,CDC20,FZR1	0.8113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons