DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: DEG_SPOP_SBC_1

Location: 706:710

E3 ligase: SPOP

DEGRON score: 0.9811

ASA_SCORE: 79.9

COIL: 0.7904

CONS_SCORE: 0.2927

DSS_SCORE: 0.7497

HELIX: 0.0622

FCONS_SCORE: 0.8512

RIG_SCORE: 0.5798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R703C	TCGA-32-2638	GBM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.R703C	TCGA-PK-A5HB	ACC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.G701R	TCGA-A6-5661	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1944
p.R719H	TCGA-AP-A051	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0833
p.S717C	TCGA-ED-A459	LIHC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.5833
p.P719S	DO228075	EOPC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.D717Y	DO228986	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5833
p.D717Y	DO229041	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5833
p.R700W	DO229055	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.6111
p.R700W	DO41927	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.6111
p.S703L	DO23846	LUAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.E720D	DO26814	LUSC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.N708K	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.6918
p.R713G	DO229272	THCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.K701N	SIDM00193	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1944
p.K701N	SNU-81	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.1944
p.K700N	SNU-81	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.6111
p.R714Q	SNU-81	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.R696W	LoVo	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.5
p.R702W	LoVo	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.S712T	C3A	liver	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons