DegronMD

Uniprot ID: Q96E39

Source protein: RNA binding motif protein, X-linked-like-1

Source gene: RBMXL1

Class: DEG_SPOP_SBC_1

Location: 171:175

E3 ligase: SPOP

DEGRON score: 0.9696

ASA_SCORE: 86.1

COIL: 0.9206

CONS_SCORE: 0.2708

DSS_SCORE: 0.7494

HELIX: 0.0408

FCONS_SCORE: 0.9813

RIG_SCORE: 0.5645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R172C	TCGA-06-5416	GBM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	TCGA-EO-A22X	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	TCGA-HF-A5NB	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	DO10880	GBM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	DO50127	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	DO43907	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172C	ACH-001991	Primary	CCLE	VRSSS	DEG_SPOP_SBC_1	0.719
p.R172H	TCGA-13-1477	OV	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7133
p.R172H	TCGA-B5-A11E	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7133
p.R172H	DO27978	OV	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7133
p.R172H	DO41644	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7133
p.R185H	TCGA-A8-A09Z	BRCA	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0556
p.R185H	DO5521	BRCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.R185H	SIDM01109	Other Sarcomas	GDSC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.R185H	ACH-000145	Sarcoma	CCLE	VRSSS	DEG_SPOP_SBC_1	0.0556
p.R185H	SK-LMS-1	soft_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.G178R	TCGA-AP-A1DK	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.G178R	DO42033	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.R185C	TCGA-AX-A3FS	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0556
p.R185C	DO40879	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.P162L	TCGA-D3-A3MR	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0833
p.P162L	DO47256	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.P162S	TCGA-D3-A3MR	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0833
p.P162S	DO47256	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.S161P	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5
p.S161P	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5
p.S161P	DO228939	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5
p.S161P	DO23525	LIRI	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5
p.S161P	DO232828	PBCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.5
p.L170P	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.L170P	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.L183V	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.L183V	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.S174N	SIDM00839	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.7069
p.S174N	ACH-000950	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.7069
p.S174N	LoVo	large_intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.7069
p.R185L	ACH-002834	Bone Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSSS

Degron related mutations and impact score

Drug responses associated with RBMXL1 mutations

All proteins holding degron of VRSSS