DegronMD

Uniprot ID: A8K979

Source protein: ERI1 exoribonuclease 2

Source gene: ERI2

Class: DEG_SPOP_SBC_1

Location: 565:569

E3 ligase: SPOP

DEGRON score: 0.9149

ASA_SCORE: 81.1

COIL: 0.8502

CONS_SCORE: 0.379

DSS_SCORE: 0.4866

HELIX: 0.1104

FCONS_SCORE: 0.9521

RIG_SCORE: 0.6856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C578Y	DO51734	COAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.T574K	DO228946	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1944
p.D579E	DO228948	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.T564K	DO229031	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.P560Q	DO43154	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1944
p.I577F	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons