DegronMD - Q96E39(RBMXL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R172C	TCGA-06-5416	GBM	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	TCGA-EO-A22X	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	TCGA-HF-A5NB	STAD	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	DO10880	GBM	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	DO50127	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	DO43907	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172C	ACH-001991	Primary	CCLE	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.719
p.R172H	TCGA-13-1477	OV	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7133
p.R172H	TCGA-B5-A11E	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7133
p.R172H	DO27978	OV	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7133
p.R172H	DO41644	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7133
p.H275Y	TCGA-21-1079	LUSC	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.6118
p.H275Y	DO26846	LUSC	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.6118
p.R309C	TCGA-2W-A8YY	CESC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.R309C	DO223732	CESC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.G305C	TCGA-39-5016	LUSC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.3056
p.G305C	TCGA-70-6722	LUSC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.3056
p.G305C	DO27755	LUSC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.3056
p.G305C	DO26701	LUSC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.3056
p.Y310C	TCGA-55-7725	LUAD	TCGA	PPSY	ITCH	301:304	Mutation blocking phosphorylation signal	0.6111
p.Y310C	DO24636	LUAD	ICGC	PPSY	ITCH	301:304	Mutation blocking phosphorylation signal	0.6111
p.P295S	TCGA-69-7974	LUAD	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1667
p.P295S	DO23850	LUAD	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1667
p.R185H	TCGA-A8-A09Z	BRCA	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R185H	DO5521	BRCA	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R185H	SIDM01109	Other Sarcomas	GDSC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R185H	ACH-000145	Sarcoma	CCLE	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R185H	SK-LMS-1	soft tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.G178R	TCGA-AP-A1DK	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.G178R	DO42033	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.R298Q	TCGA-AX-A06F	UCEC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.25
p.R298Q	DO41752	UCEC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.25
p.R185C	TCGA-AX-A3FS	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R185C	DO40879	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.R263I	TCGA-B5-A0JY	UCEC	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.1667
p.R263I	DO43041	UCEC	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.1667
p.R309H	TCGA-B5-A3FA	UCEC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.R309H	TCGA-DK-A6AW	BLCA	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.R309H	DO48566	BLCA	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.R309H	DO52402	UCEC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.P162L	TCGA-D3-A3MR	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P162L	DO47256	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P162S	TCGA-D3-A3MR	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.P162S	DO47256	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.Y266C	TCGA-F7-A624	HNSC	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.25
p.Y266C	DO44440	HNSC	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.25
p.R292H	TCGA-FG-6690	LGG	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.0833
p.R292H	DO22141	LGG	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.0833
p.R292C	TCGA-HD-A4C1	HNSC	TCGA	PPSY	ITCH	301:304	Mutation rewiring degron network	0.0833
p.R292C	DO44453	HNSC	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.0833
p.G261C	TCGA-HQ-A5ND	BLCA	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.1111
p.G261C	DO51899	BLCA	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.1111
p.R270H	TCGA-HU-A4GD	STAD	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.7133
p.R270H	DO232761	PBCA	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.7133
p.R270H	DO47725	STAD	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.7133
p.S273L	TCGA-LN-A4A5	ESCA	TCGA	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.8778
p.G267D	DO225108	BRCA	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.2778
p.S161P	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5
p.S161P	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5
p.S161P	DO228939	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5
p.S161P	DO23525	LIRI	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5
p.S161P	DO232828	PBCA	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation blocking phosphorylation signal	0.5
p.L170P	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.3056
p.L170P	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.3056
p.L183V	DO229496	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.L183V	DO229512	LAML	ICGC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.L296P	DO229512	LAML	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.L296P	DO228950	LICA	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.L296P	DO228963	LICA	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.L296P	DO33128	PACA	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.L296P	DO33037	PACA	ICGC	PPSY	ITCH	301:304	Mutation rewiring degron network	0.1944
p.S307I	DO229034	LICA	ICGC	PPSY	ITCH	301:304	Mutation blocking phosphorylation signal	0.6944
p.G261S	DO231114	LUSC	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.1111
p.R270C	DO220909	MELA	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.719
p.S314G	DO229268	THCA	ICGC	PPSY	ITCH	301:304	Mutation blocking phosphorylation signal	0.5
p.G259D	DO229227	THCA	ICGC	DRDYSDHP	CBL_PTK	269:276	Mutation rewiring degron network	0.0556
p.D269N	SIDM00845	Burkitt's Lymphoma	GDSC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.5821
p.D269N	SIDM01519	Head and Neck Carcinoma	GDSC	DRDYSDHP	CBL_PTK	269:276	Mutation altering degron motif	0.5821
p.S174N	SIDM00839	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7069
p.S174N	ACH-000950	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7069
p.S174N	LoVo	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7069
p.R185L	ACH-002834	Bone Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMXL1

UniProt ID: Q96E39

Entrez ID: 494115

Protein name: RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBMXL1 in