DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DRDYSDHP
Uniprot ID:
Q96E39
Source protein:
RNA binding motif protein, X-linked-like-1
Source gene:
RBMXL1
Class:
CBL_PTK
Location:
269:276
E3 ligase:
CBL
DEGRON score:
0.9977
ASA_SCORE:
77.2625
COIL:
0.9143
CONS_SCORE:
0.2843
DSS_SCORE:
0.6388
HELIX:
0.0525
FCONS_SCORE:
0.8144
RIG_SCORE:
0.6365
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H275Y
TCGA-21-1079
LUSC
TCGA
DRDYSDHP
CBL_PTK
0.6118
p.H275Y
DO26846
LUSC
ICGC
DRDYSDHP
CBL_PTK
0.6118
p.R263I
TCGA-B5-A0JY
UCEC
TCGA
DRDYSDHP
CBL_PTK
0.1667
p.R263I
DO43041
UCEC
ICGC
DRDYSDHP
CBL_PTK
0.1667
p.Y266C
TCGA-F7-A624
HNSC
TCGA
DRDYSDHP
CBL_PTK
0.25
p.Y266C
DO44440
HNSC
ICGC
DRDYSDHP
CBL_PTK
0.25
p.G261C
TCGA-HQ-A5ND
BLCA
TCGA
DRDYSDHP
CBL_PTK
0.1111
p.G261C
DO51899
BLCA
ICGC
DRDYSDHP
CBL_PTK
0.1111
p.R270H
TCGA-HU-A4GD
STAD
TCGA
DRDYSDHP
CBL_PTK
0.7133
p.R270H
DO232761
PBCA
ICGC
DRDYSDHP
CBL_PTK
0.7133
p.R270H
DO47725
STAD
ICGC
DRDYSDHP
CBL_PTK
0.7133
p.S273L
TCGA-LN-A4A5
ESCA
TCGA
DRDYSDHP
CBL_PTK
0.8778
p.G267D
DO225108
BRCA
ICGC
DRDYSDHP
CBL_PTK
0.2778
p.G261S
DO231114
LUSC
ICGC
DRDYSDHP
CBL_PTK
0.1111
p.R270C
DO220909
MELA
ICGC
DRDYSDHP
CBL_PTK
0.719
p.G259D
DO229227
THCA
ICGC
DRDYSDHP
CBL_PTK
0.0556
p.D269N
SIDM00845
Burkitt's Lymphoma
GDSC
DRDYSDHP
CBL_PTK
0.5821
p.D269N
SIDM01519
Head and Neck Carcinoma
GDSC
DRDYSDHP
CBL_PTK
0.5821
Drug responses associated with RBMXL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRDYSDHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P38159
RNA-binding motif protein, X chromosome
CBL_PTK
269:276
DRDYSDHP
CBL
0.9985
More...
Q96E39
RNA binding motif protein, X-linked-like-1
CBL_PTK
269:276
DRDYSDHP
CBL
0.9977
More...
