DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DRDYSDHP
Uniprot ID:
P38159
Source protein:
RNA-binding motif protein, X chromosome
Source gene:
RBMX
Class:
CBL_PTK
Location:
269:276
E3 ligase:
CBL
DEGRON score:
0.9985
ASA_SCORE:
77.7375
COIL:
0.906
CONS_SCORE:
0.4696
DSS_SCORE:
0.653
HELIX:
0.0598
FCONS_SCORE:
1.1631
RIG_SCORE:
0.6252
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G259R
TCGA-AP-A059
UCEC
TCGA
DRDYSDHP
CBL_PTK
0.0556
p.R270C
TCGA-B5-A3FA
UCEC
TCGA
DRDYSDHP
CBL_PTK
0.719
p.E286K
TCGA-BF-A5ES
SKCM
TCGA
DRDYSDHP
CBL_PTK
0.0556
p.S261I
TCGA-DZ-6133
KIRP
TCGA
DRDYSDHP
CBL_PTK
0.5556
p.R282T
TCGA-PL-A8LV
BRCA
TCGA
DRDYSDHP
CBL_PTK
0.1667
p.R262S
DO43530
UCEC
ICGC
DRDYSDHP
CBL_PTK
0.1389
p.G259D
DO43186
UCEC
ICGC
DRDYSDHP
CBL_PTK
0.0556
p.G259S
DO41927
UCEC
ICGC
DRDYSDHP
CBL_PTK
0.0556
Drug responses associated with RBMX mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRDYSDHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P38159
RNA-binding motif protein, X chromosome
CBL_PTK
269:276
DRDYSDHP
CBL
0.9985
More...
Q96E39
RNA binding motif protein, X-linked-like-1
CBL_PTK
269:276
DRDYSDHP
CBL
0.9977
More...
