FUNCTION: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates...
FUNCTION: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. {ECO:0000250|UniProtKB:Q6PDH4, ECO:0000269|PubMed:25755279}.
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GO - Biological processes (BP):
mesenchymal cell differentiation involved in bone development [GO:1901706]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of myoblast differentiation [GO:0045663]; protein export from nucleus [GO:0006611]; regulation of catalytic activity [GO:0050790]...
mesenchymal cell differentiation involved in bone development [GO:1901706]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of myoblast differentiation [GO:0045663]; protein export from nucleus [GO:0006611]; regulation of catalytic activity [GO:0050790]
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GO - Molecular function (MF):
SMAD binding [GO:0046332]...
SMAD binding [GO:0046332]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nuclear pore [GO:0005643]...
cytoplasm [GO:0005737]; nuclear pore [GO:0005643]
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